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Anti-BMP2/ BDA2A/ SSFSC monoclonal antibody
Anti-BMP2/ BDA2A/ SSFSC antibody for FACS & in-vivo assay
Go to BMP2/BMP2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T68383-Ab-1/ GM-Tg-hg-T68383-Ab-2 | Anti-Human BMP2 monoclonal antibody | Human |
| GM-Tg-rg-T68383-Ab-1/ GM-Tg-rg-T68383-Ab-2 | Anti-Rat BMP2 monoclonal antibody | Rat |
| GM-Tg-mg-T68383-Ab-1/ GM-Tg-mg-T68383-Ab-2 | Anti-Mouse BMP2 monoclonal antibody | Mouse |
| GM-Tg-cynog-T68383-Ab-1/ GM-Tg-cynog-T68383-Ab-2 | Anti-Cynomolgus/ Rhesus macaque BMP2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T68383-Ab-1/ GM-Tg-felg-T68383-Ab-2 | Anti-Feline BMP2 monoclonal antibody | Feline |
| GM-Tg-cang-T68383-Ab-1/ GM-Tg-cang-T68383-Ab-2 | Anti-Canine BMP2 monoclonal antibody | Canine |
| GM-Tg-bovg-T68383-Ab-1/ GM-Tg-bovg-T68383-Ab-2 | Anti-Bovine BMP2 monoclonal antibody | Bovine |
| GM-Tg-equg-T68383-Ab-1/ GM-Tg-equg-T68383-Ab-2 | Anti-Equine BMP2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T68383-Ab-1/ GM-Tg-hg-T68383-Ab-2; GM-Tg-rg-T68383-Ab-1/ GM-Tg-rg-T68383-Ab-2; GM-Tg-mg-T68383-Ab-1/ GM-Tg-mg-T68383-Ab-2; GM-Tg-cynog-T68383-Ab-1/ GM-Tg-cynog-T68383-Ab-2; GM-Tg-felg-T68383-Ab-1/ GM-Tg-felg-T68383-Ab-2; GM-Tg-cang-T68383-Ab-1/ GM-Tg-cang-T68383-Ab-2; GM-Tg-bovg-T68383-Ab-1/ GM-Tg-bovg-T68383-Ab-2; GM-Tg-equg-T68383-Ab-1/ GM-Tg-equg-T68383-Ab-2 |
| Products Name | Anti-BMP2 monoclonal antibody |
| Format | mab |
| Target Name | BMP2 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-BMP2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species BMP2/ BDA2A/ SSFSC VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-T68383-Ag-1 | bone morphogenetic protein 2 (BMP2) protein |
| ORF Viral Vector | pGMLP002836 | human BMP2 Lentivirus plasmid |
| ORF Viral Vector | vGMLP002836 | human BMP2 Lentivirus particle |
| ORF Viral Vector | pGMAD000553 | human BMP2 Adenovirus plasmid |
| ORF Viral Vector | vGMAD000553 | human BMP2 Adenovirus particle |
| ORF Viral Vector | pGMLV000859 | house mouse Bmp2 Lentivirus plasmid |
| ORF Viral Vector | pGMAD000286 | rat Bmp2 Adenovirus plasmid |
| ORF Viral Vector | pGMLPm005137 | mouse Bmp2 Lentivirus plasmid |
| ORF Viral Vector | vGMLV000859 | house mouse Bmp2 Lentivirus particle |
| ORF Viral Vector | vGMAD000286 | rat Bmp2 Adenovirus particle |
| ORF Viral Vector | vGMLPm005137 | mouse Bmp2 Lentivirus particle |
Target information
| Target ID | GM-T68383 |
| Target Name | BMP2 |
| Gene ID | 650,12156,29373,718330,477162,100301987,615037,100051701 |
| Gene Symbol and Synonyms | BDA2,BMP2,BMP2A,SSFSC,SSFSC1 |
| Uniprot Accession | P12643,P49001 |
| Uniprot Entry Name | BMP2_HUMAN,BMP2_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Cytokine Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000125845 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: BMP2, gene name: BMP2, also named as BDA2A, SSFSC, BMP2. This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients. [provided by RefSeq, Jul 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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