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Anti-CDK2 monoclonal antibody
Pre-made anti-CDK2 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to CDK2/CDK2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T70176-Ab-1/ GM-Tg-hg-T70176-Ab-2 | Anti-Human CDK2 monoclonal antibody | Human |
| GM-Tg-rg-T70176-Ab-1/ GM-Tg-rg-T70176-Ab-2 | Anti-Rat CDK2 monoclonal antibody | Rat |
| GM-Tg-mg-T70176-Ab-1/ GM-Tg-mg-T70176-Ab-2 | Anti-Mouse CDK2 monoclonal antibody | Mouse |
| GM-Tg-cynog-T70176-Ab-1/ GM-Tg-cynog-T70176-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CDK2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T70176-Ab-1/ GM-Tg-felg-T70176-Ab-2 | Anti-Feline CDK2 monoclonal antibody | Feline |
| GM-Tg-cang-T70176-Ab-1/ GM-Tg-cang-T70176-Ab-2 | Anti-Canine CDK2 monoclonal antibody | Canine |
| GM-Tg-bovg-T70176-Ab-1/ GM-Tg-bovg-T70176-Ab-2 | Anti-Bovine CDK2 monoclonal antibody | Bovine |
| GM-Tg-equg-T70176-Ab-1/ GM-Tg-equg-T70176-Ab-2 | Anti-Equine CDK2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T70176-Ab-1/ GM-Tg-hg-T70176-Ab-2; GM-Tg-rg-T70176-Ab-1/ GM-Tg-rg-T70176-Ab-2; GM-Tg-mg-T70176-Ab-1/ GM-Tg-mg-T70176-Ab-2; GM-Tg-cynog-T70176-Ab-1/ GM-Tg-cynog-T70176-Ab-2; GM-Tg-felg-T70176-Ab-1/ GM-Tg-felg-T70176-Ab-2; GM-Tg-cang-T70176-Ab-1/ GM-Tg-cang-T70176-Ab-2; GM-Tg-bovg-T70176-Ab-1/ GM-Tg-bovg-T70176-Ab-2; GM-Tg-equg-T70176-Ab-1/ GM-Tg-equg-T70176-Ab-2 |
| Products Name | Anti-CDK2 monoclonal antibody |
| Format | mab |
| Target Name | CDK2 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-CDK2 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T70176-Ag-1 | Recombinant multi-species CDK2/ CDKN2/ p33(CDK2) protein |
| ORF Viral Vector | vGMLP000522 | human CDK2 Lentivirus particle |
| ORF Viral Vector | pGMAP000235 | Human CDK2 Adenovirus plasmid |
| ORF Viral Vector | vGMAP000235 | Human CDK2 Adenovirus particle |
| ORF Viral Vector | pGMLP000522 | human CDK2 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm003869 | mouse Cdk2 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm003869 | mouse Cdk2 Lentivirus particle |
Target information
| Target ID | GM-T70176 |
| Target Name | CDK2 |
| Gene ID | 1017,12566,362817,711002,100855704,101093368,519217,100051790 |
| Gene Symbol and Synonyms | A630093N05Rik,CDK2,CDKN2,p33(CDK2) |
| Uniprot Accession | P24941,Q63699,Q5E9Y0 |
| Uniprot Entry Name | CDK2_HUMAN,CDK2_RAT,CDK2_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000123374 |
| Target Classification | Kinase, Tumor-associated antigen (TAA) |
The target: CDK2, gene name: CDK2, also named as CDKN2, p33(CDK2). This gene encodes a member of a family of serine/threonine protein kinases that participate in cell cycle regulation. The encoded protein is the catalytic subunit of the cyclin-dependent protein kinase complex, which regulates progression through the cell cycle. Activity of this protein is especially critical during the G1 to S phase transition. This protein associates with and regulated by other subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A), and p27Kip1 (CDKN1B). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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