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Anti-S22A8/ SLC22A8/ OAT3 monoclonal antibody
Anti-S22A8/ SLC22A8/ OAT3 antibody for FACS & in-vivo assay
Go to SLC22A8/SLC22A8 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T70680-Ab-1/ GM-Tg-hg-T70680-Ab-2 | Anti-Human SLC22A8 monoclonal antibody | Human |
| GM-Tg-rg-T70680-Ab-1/ GM-Tg-rg-T70680-Ab-2 | Anti-Rat SLC22A8 monoclonal antibody | Rat |
| GM-Tg-mg-T70680-Ab-1/ GM-Tg-mg-T70680-Ab-2 | Anti-Mouse SLC22A8 monoclonal antibody | Mouse |
| GM-Tg-cynog-T70680-Ab-1/ GM-Tg-cynog-T70680-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SLC22A8 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T70680-Ab-1/ GM-Tg-felg-T70680-Ab-2 | Anti-Feline SLC22A8 monoclonal antibody | Feline |
| GM-Tg-cang-T70680-Ab-1/ GM-Tg-cang-T70680-Ab-2 | Anti-Canine SLC22A8 monoclonal antibody | Canine |
| GM-Tg-bovg-T70680-Ab-1/ GM-Tg-bovg-T70680-Ab-2 | Anti-Bovine SLC22A8 monoclonal antibody | Bovine |
| GM-Tg-equg-T70680-Ab-1/ GM-Tg-equg-T70680-Ab-2 | Anti-Equine SLC22A8 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T70680-Ab-1/ GM-Tg-hg-T70680-Ab-2; GM-Tg-rg-T70680-Ab-1/ GM-Tg-rg-T70680-Ab-2; GM-Tg-mg-T70680-Ab-1/ GM-Tg-mg-T70680-Ab-2; GM-Tg-cynog-T70680-Ab-1/ GM-Tg-cynog-T70680-Ab-2; GM-Tg-felg-T70680-Ab-1/ GM-Tg-felg-T70680-Ab-2; GM-Tg-cang-T70680-Ab-1/ GM-Tg-cang-T70680-Ab-2; GM-Tg-bovg-T70680-Ab-1/ GM-Tg-bovg-T70680-Ab-2; GM-Tg-equg-T70680-Ab-1/ GM-Tg-equg-T70680-Ab-2 |
| Products Name | Anti-SLC22A8 monoclonal antibody |
| Format | mab |
| Target Name | SLC22A8 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-SLC22A8 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species S22A8/ SLC22A8/ OAT3 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLV000246 | human SLC22A8 Lentivirus particle |
| ORF Viral Vector | pGMLV000246 | human SLC22A8 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm004328 | mouse Slc22a8 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004328 | mouse Slc22a8 Lentivirus particle |
Target information
| Target ID | GM-T70680 |
| Target Name | SLC22A8 |
| Gene ID | 9376,19879,83500,718363,476049,101088955,100064251 |
| Gene Symbol and Synonyms | OAT3,OCT3,Roct,SLC22A8 |
| Uniprot Accession | Q8TCC7,Q9R1U7 |
| Uniprot Entry Name | S22A8_HUMAN,S22A8_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000149452 |
| Target Classification | N/A |
The target: SLC22A8, gene name: SLC22A8, also named as OAT3. This gene encodes a protein involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, May 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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