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Anti-FOXO1 monoclonal antibody
Pre-made anti-FOXO1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to FOXO1/FOXO1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T72850-Ab-1/ GM-Tg-hg-T72850-Ab-2 | Anti-Human FOXO1 monoclonal antibody | Human |
| GM-Tg-rg-T72850-Ab-1/ GM-Tg-rg-T72850-Ab-2 | Anti-Rat FOXO1 monoclonal antibody | Rat |
| GM-Tg-mg-T72850-Ab-1/ GM-Tg-mg-T72850-Ab-2 | Anti-Mouse FOXO1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T72850-Ab-1/ GM-Tg-cynog-T72850-Ab-2 | Anti-Cynomolgus/ Rhesus macaque FOXO1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T72850-Ab-1/ GM-Tg-felg-T72850-Ab-2 | Anti-Feline FOXO1 monoclonal antibody | Feline |
| GM-Tg-cang-T72850-Ab-1/ GM-Tg-cang-T72850-Ab-2 | Anti-Canine FOXO1 monoclonal antibody | Canine |
| GM-Tg-bovg-T72850-Ab-1/ GM-Tg-bovg-T72850-Ab-2 | Anti-Bovine FOXO1 monoclonal antibody | Bovine |
| GM-Tg-equg-T72850-Ab-1/ GM-Tg-equg-T72850-Ab-2 | Anti-Equine FOXO1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T72850-Ab-1/ GM-Tg-hg-T72850-Ab-2; GM-Tg-rg-T72850-Ab-1/ GM-Tg-rg-T72850-Ab-2; GM-Tg-mg-T72850-Ab-1/ GM-Tg-mg-T72850-Ab-2; GM-Tg-cynog-T72850-Ab-1/ GM-Tg-cynog-T72850-Ab-2; GM-Tg-felg-T72850-Ab-1/ GM-Tg-felg-T72850-Ab-2; GM-Tg-cang-T72850-Ab-1/ GM-Tg-cang-T72850-Ab-2; GM-Tg-bovg-T72850-Ab-1/ GM-Tg-bovg-T72850-Ab-2; GM-Tg-equg-T72850-Ab-1/ GM-Tg-equg-T72850-Ab-2 |
| Products Name | Anti-FOXO1 monoclonal antibody |
| Format | mab |
| Target Name | FOXO1 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-FOXO1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T72850-Ag-1 | Recombinant multi-species FOXO1/ FKH1/ FKHRA protein |
| ORF Viral Vector | vGMLV000310 | human FOXO1 Lentivirus particle |
| ORF Viral Vector | vGMAD000137 | human FOXO1 Adenovirus particle |
| ORF Viral Vector | vGMAD000525 | human FOXO1 Adenovirus particle |
| ORF Viral Vector | pGMLV000310 | human FOXO1 Lentivirus plasmid |
| ORF Viral Vector | pGMAD000525 | human FOXO1 Adenovirus plasmid |
| ORF Viral Vector | pGMAD000137 | human FOXO1 Adenovirus plasmid |
| ORF Viral Vector | pGMAD000298 | mouse Foxo1 Adenovirus plasmid |
| ORF Viral Vector | pGMAAV000223 | house mouse Foxo1 AAV plasmid |
| ORF Viral Vector | vGMAD000298 | mouse Foxo1 Adenovirus particle |
| ORF Viral Vector | vGMAAV000223 | house mouse Foxo1 AAV particle |
Target information
| Target ID | GM-T72850 |
| Target Name | FOXO1 |
| Gene ID | 2308,56458,84482,700030,477295,101096628,506618,100050481 |
| Gene Symbol and Synonyms | Afxh,FKH1,FKHR,Fkhr1,FOXO1,FOXO1A |
| Uniprot Accession | Q12778,G3V7R4,E1BPQ1 |
| Uniprot Entry Name | FOXO1_HUMAN,FOXO1_RAT,FOXO1_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000150907 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: FOXO1, gene name: FOXO1, also named as FKH1, FKHRA, FOXO1. This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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