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Anti-AGTR1/ AG2SB/ AT1 monoclonal antibody
Anti-AGTR1/ AG2SB/ AT1 antibody for FACS & in-vivo assay
Go to AGTR1/AGTR1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T74456-Ab-1/ GM-Tg-hg-T74456-Ab-2 | Anti-Human AGTR1 monoclonal antibody | Human |
| GM-Tg-rg-T74456-Ab-1/ GM-Tg-rg-T74456-Ab-2 | Anti-Rat AGTR1 monoclonal antibody | Rat |
| GM-Tg-mg-T74456-Ab-1/ GM-Tg-mg-T74456-Ab-2 | Anti-Mouse AGTR1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T74456-Ab-1/ GM-Tg-cynog-T74456-Ab-2 | Anti-Cynomolgus/ Rhesus macaque AGTR1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T74456-Ab-1/ GM-Tg-felg-T74456-Ab-2 | Anti-Feline AGTR1 monoclonal antibody | Feline |
| GM-Tg-cang-T74456-Ab-1/ GM-Tg-cang-T74456-Ab-2 | Anti-Canine AGTR1 monoclonal antibody | Canine |
| GM-Tg-bovg-T74456-Ab-1/ GM-Tg-bovg-T74456-Ab-2 | Anti-Bovine AGTR1 monoclonal antibody | Bovine |
| GM-Tg-equg-T74456-Ab-1/ GM-Tg-equg-T74456-Ab-2 | Anti-Equine AGTR1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T74456-Ab-1/ GM-Tg-hg-T74456-Ab-2; GM-Tg-rg-T74456-Ab-1/ GM-Tg-rg-T74456-Ab-2; GM-Tg-mg-T74456-Ab-1/ GM-Tg-mg-T74456-Ab-2; GM-Tg-cynog-T74456-Ab-1/ GM-Tg-cynog-T74456-Ab-2; GM-Tg-felg-T74456-Ab-1/ GM-Tg-felg-T74456-Ab-2; GM-Tg-cang-T74456-Ab-1/ GM-Tg-cang-T74456-Ab-2; GM-Tg-bovg-T74456-Ab-1/ GM-Tg-bovg-T74456-Ab-2; GM-Tg-equg-T74456-Ab-1/ GM-Tg-equg-T74456-Ab-2 |
| Products Name | Anti-AGTR1 monoclonal antibody |
| Format | mab |
| Target Name | AGTR1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-AGTR1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species AGTR1/ AG2SB/ AT1 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLV000160 | human AGTR1 Lentivirus plasmid |
| ORF Viral Vector | vGMLV000160 | human AGTR1 Lentivirus particle |
| ORF Viral Vector | pGMAD000019 | human AGTR1 Adenovirus plasmid |
| ORF Viral Vector | vGMAD000019 | human AGTR1 Adenovirus particle |
| ORF Viral Vector | pGMLPm001804 | mouse Agtr1a Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001804 | mouse Agtr1a Lentivirus particle |
Target information
| Target ID | GM-T74456 |
| Target Name | AGTR1 |
| Gene ID | 185,11608,81638,712773,403836,101082936,281607,100059005 |
| Gene Symbol and Synonyms | AG2S,Agtr-1b,AGTR1,AGTR1B,Angtr-1b,AT1,AT1AR,AT1B,AT1BR,AT1R,AT2R1,AT2R1B,AT3,AT1R,ATR1,HAT1R |
| Uniprot Accession | P30556,P29089,P43240,P25104 |
| Uniprot Entry Name | AGTR1_HUMAN,AGTRB_RAT,AGTR1_CANLF,AGTR1_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000144891 |
| Target Classification | GPCR |
The target: AGTR1, gene name: AGTR1, also named as AG2SB, AT1, AT1AR, AT1B, AT1BR, AT1R, AT2R1, HAT1R, AGTR1. Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2020].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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