Anti-SCN3A/ EIEE62/ FFEVF4 monoclonal antibody
Anti-SCN3A/ EIEE62/ FFEVF4 antibody for FACS & in-vivo assay
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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T76937-Ab-1/ GM-Tg-hg-T76937-Ab-2 | Anti-Human SCN3A monoclonal antibody | Human |
GM-Tg-rg-T76937-Ab-1/ GM-Tg-rg-T76937-Ab-2 | Anti-Rat SCN3A monoclonal antibody | Rat |
GM-Tg-mg-T76937-Ab-1/ GM-Tg-mg-T76937-Ab-2 | Anti-Mouse SCN3A monoclonal antibody | Mouse |
GM-Tg-cynog-T76937-Ab-1/ GM-Tg-cynog-T76937-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SCN3A monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T76937-Ab-1/ GM-Tg-felg-T76937-Ab-2 | Anti-Feline SCN3A monoclonal antibody | Feline |
GM-Tg-cang-T76937-Ab-1/ GM-Tg-cang-T76937-Ab-2 | Anti-Canine SCN3A monoclonal antibody | Canine |
GM-Tg-bovg-T76937-Ab-1/ GM-Tg-bovg-T76937-Ab-2 | Anti-Bovine SCN3A monoclonal antibody | Bovine |
GM-Tg-equg-T76937-Ab-1/ GM-Tg-equg-T76937-Ab-2 | Anti-Equine SCN3A monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T76937-Ab-1/ GM-Tg-hg-T76937-Ab-2; GM-Tg-rg-T76937-Ab-1/ GM-Tg-rg-T76937-Ab-2; GM-Tg-mg-T76937-Ab-1/ GM-Tg-mg-T76937-Ab-2; GM-Tg-cynog-T76937-Ab-1/ GM-Tg-cynog-T76937-Ab-2; GM-Tg-felg-T76937-Ab-1/ GM-Tg-felg-T76937-Ab-2; GM-Tg-cang-T76937-Ab-1/ GM-Tg-cang-T76937-Ab-2; GM-Tg-bovg-T76937-Ab-1/ GM-Tg-bovg-T76937-Ab-2; GM-Tg-equg-T76937-Ab-1/ GM-Tg-equg-T76937-Ab-2 |
Products Name | Anti-SCN3A monoclonal antibody |
Format | mab |
Target Name | SCN3A |
Protein Sub-location | Transmembrane Protein |
Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-SCN3A benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | Products Developing | Multi-species SCN3A/ EIEE62/ FFEVF4 VLP (virus-like particle) (Products Developing) |
Target information
Target ID | GM-T76937 |
Target Name | SCN3A |
Gene ID | 6328,20269,497770,703178,478772,101082587,534223,100061941 |
Gene Symbol and Synonyms | DEE62,EIEE62,FFEVF4,Gm1000,NAC3,Nav1.3,SCIII,Scn2a,SCN3A |
Uniprot Accession | Q9NY46,P08104 |
Uniprot Entry Name | SCN3A_HUMAN,SCN3A_RAT |
Protein Sub-location | Transmembrane Protein |
Category | Therapeutics Target |
Disease | N/A |
Gene Ensembl | ENSG00000153253 |
Target Classification | Ion Channel |
The target: SCN3A, gene name: SCN3A, also named as EIEE62, FFEVF4, NAC3, Nav1.3. Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is found in a cluster of five alpha subunit genes on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.