Anti-PDE2A monoclonal antibody
Pre-made anti-PDE2A monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T77400-Ab-1/ GM-Tg-hg-T77400-Ab-2 | Anti-Human PDE2A monoclonal antibody | Human |
GM-Tg-rg-T77400-Ab-1/ GM-Tg-rg-T77400-Ab-2 | Anti-Rat PDE2A monoclonal antibody | Rat |
GM-Tg-mg-T77400-Ab-1/ GM-Tg-mg-T77400-Ab-2 | Anti-Mouse PDE2A monoclonal antibody | Mouse |
GM-Tg-cynog-T77400-Ab-1/ GM-Tg-cynog-T77400-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PDE2A monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T77400-Ab-1/ GM-Tg-felg-T77400-Ab-2 | Anti-Feline PDE2A monoclonal antibody | Feline |
GM-Tg-cang-T77400-Ab-1/ GM-Tg-cang-T77400-Ab-2 | Anti-Canine PDE2A monoclonal antibody | Canine |
GM-Tg-bovg-T77400-Ab-1/ GM-Tg-bovg-T77400-Ab-2 | Anti-Bovine PDE2A monoclonal antibody | Bovine |
GM-Tg-equg-T77400-Ab-1/ GM-Tg-equg-T77400-Ab-2 | Anti-Equine PDE2A monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T77400-Ab-1/ GM-Tg-hg-T77400-Ab-2; GM-Tg-rg-T77400-Ab-1/ GM-Tg-rg-T77400-Ab-2; GM-Tg-mg-T77400-Ab-1/ GM-Tg-mg-T77400-Ab-2; GM-Tg-cynog-T77400-Ab-1/ GM-Tg-cynog-T77400-Ab-2; GM-Tg-felg-T77400-Ab-1/ GM-Tg-felg-T77400-Ab-2; GM-Tg-cang-T77400-Ab-1/ GM-Tg-cang-T77400-Ab-2; GM-Tg-bovg-T77400-Ab-1/ GM-Tg-bovg-T77400-Ab-2; GM-Tg-equg-T77400-Ab-1/ GM-Tg-equg-T77400-Ab-2 |
Products Name | Anti-PDE2A monoclonal antibody |
Format | mab |
Target Name | PDE2A |
Protein Sub-location | Introcelluar Protein |
Category of antibody | Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
Tag | Fc |
Products description | Pre-made anti-PDE2A monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation | Lyophilized from sterile PBS, PH 7.4 |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | GM-Tg-g-T77400-Ag-1 | Recombinant multi-species PDE2A/ CGS-PDE1/ PED2A4 protein |
Target information
Target ID | GM-T77400 |
Target Name | PDE2A |
Gene ID | 5138,207728,81743,718479,609574,101083366,281971,100052619 |
Gene Symbol and Synonyms | CGS-PDE,cGSPDE,IDDPADS,Pde2,PDE2A,PDE2A1,Pde2a2,PED2A4 |
Uniprot Accession | O00408,Q01062,P14099 |
Uniprot Entry Name | PDE2A_HUMAN,PDE2A_RAT,PDE2A_BOVIN |
Protein Sub-location | Introcelluar Protein |
Category | Therapeutics Target |
Disease | IgA glomerulonephritis |
Gene Ensembl | ENSG00000186642 |
Target Classification | N/A |
The target: PDE2A, gene name: PDE2A, also named as CGS-PDE1, PED2A4, cGSPDE, PDE2A. Enables several functions, including 3',5'-cyclic-nucleotide phosphodiesterase activity; anion binding activity; and metal ion binding activity. Involved in several processes, including cellular response to organic cyclic compound; cyclic-nucleotide-mediated signaling; and regulation of vascular permeability. Located in several cellular components, including cytosol; mitochondrial membrane; and perinuclear region of cytoplasm. Colocalizes with plasma membrane. [provided by Alliance of Genome Resources, Apr 2022].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.