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Anti-DAF/ CD55/ CHAPLE monoclonal antibody
Anti-DAF/ CD55/ CHAPLE antibody for FACS & in-vivo assay
Go to CD55/CD55 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T78114-Ab-1/ GM-Tg-hg-T78114-Ab-2 | Anti-Human CD55 monoclonal antibody | Human |
| GM-Tg-rg-T78114-Ab-1/ GM-Tg-rg-T78114-Ab-2 | Anti-Rat CD55 monoclonal antibody | Rat |
| GM-Tg-mg-T78114-Ab-1/ GM-Tg-mg-T78114-Ab-2 | Anti-Mouse CD55 monoclonal antibody | Mouse |
| GM-Tg-cynog-T78114-Ab-1/ GM-Tg-cynog-T78114-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CD55 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T78114-Ab-1/ GM-Tg-felg-T78114-Ab-2 | Anti-Feline CD55 monoclonal antibody | Feline |
| GM-Tg-cang-T78114-Ab-1/ GM-Tg-cang-T78114-Ab-2 | Anti-Canine CD55 monoclonal antibody | Canine |
| GM-Tg-bovg-T78114-Ab-1/ GM-Tg-bovg-T78114-Ab-2 | Anti-Bovine CD55 monoclonal antibody | Bovine |
| GM-Tg-equg-T78114-Ab-1/ GM-Tg-equg-T78114-Ab-2 | Anti-Equine CD55 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T78114-Ab-1/ GM-Tg-hg-T78114-Ab-2; GM-Tg-rg-T78114-Ab-1/ GM-Tg-rg-T78114-Ab-2; GM-Tg-mg-T78114-Ab-1/ GM-Tg-mg-T78114-Ab-2; GM-Tg-cynog-T78114-Ab-1/ GM-Tg-cynog-T78114-Ab-2; GM-Tg-felg-T78114-Ab-1/ GM-Tg-felg-T78114-Ab-2; GM-Tg-cang-T78114-Ab-1/ GM-Tg-cang-T78114-Ab-2; GM-Tg-bovg-T78114-Ab-1/ GM-Tg-bovg-T78114-Ab-2; GM-Tg-equg-T78114-Ab-1/ GM-Tg-equg-T78114-Ab-2 |
| Products Name | Anti-CD55 monoclonal antibody |
| Format | mab |
| Target Name | CD55 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CD55 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species DAF/ CD55/ CHAPLE VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMAP000525 | Human CD55 Adenovirus plasmid |
| ORF Viral Vector | pGMAP000554 | Human CD55 Adenovirus plasmid |
| ORF Viral Vector | vGMAP000554 | Human CD55 Adenovirus particle |
| ORF Viral Vector | vGMAP000525 | Human CD55 Adenovirus particle |
| ORF Viral Vector | pGMLPm003946 | mouse Cd55 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm003946 | mouse Cd55 Lentivirus particle |
Target information
| Target ID | GM-T78114 |
| Target Name | CD55 |
| Gene ID | 1604,13136,64036,714370,609307,101094644,518609,100057656 |
| Gene Symbol and Synonyms | CD55,CHAPLE,CR,CROM,DAF,Daf-GPI,Daf1,GPI-DAF,TC |
| Uniprot Accession | P08174 |
| Uniprot Entry Name | DAF_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000196352 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: CD55, gene name: CD55, also named as CHAPLE, CR, CROM, DAF, TC. This gene encodes a glycoprotein involved in the regulation of the complement cascade. Binding of the encoded protein to complement proteins accelerates their decay, thereby disrupting the cascade and preventing damage to host cells. Antigens present on this protein constitute the Cromer blood group system (CROM). Alternative splicing results in multiple transcript variants. The predominant transcript variant encodes a membrane-bound protein, but alternatively spliced transcripts may produce soluble proteins. [provided by RefSeq, Jul 2014].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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