Anti-CD44/ CDW44/ CSPG8 monoclonal antibody

Anti-CD44/ CDW44/ CSPG8 antibody for FACS & in-vivo assay

Target products collectionGo to CD44/CD44 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T78319-Ab-1/ GM-Tg-hg-T78319-Ab-2Anti-Human CD44 monoclonal antibodyHuman
GM-Tg-rg-T78319-Ab-1/ GM-Tg-rg-T78319-Ab-2Anti-Rat CD44 monoclonal antibodyRat
GM-Tg-mg-T78319-Ab-1/ GM-Tg-mg-T78319-Ab-2Anti-Mouse CD44 monoclonal antibodyMouse
GM-Tg-cynog-T78319-Ab-1/ GM-Tg-cynog-T78319-Ab-2Anti-Cynomolgus/ Rhesus macaque CD44 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T78319-Ab-1/ GM-Tg-felg-T78319-Ab-2Anti-Feline CD44 monoclonal antibodyFeline
GM-Tg-cang-T78319-Ab-1/ GM-Tg-cang-T78319-Ab-2Anti-Canine CD44 monoclonal antibodyCanine
GM-Tg-bovg-T78319-Ab-1/ GM-Tg-bovg-T78319-Ab-2Anti-Bovine CD44 monoclonal antibodyBovine
GM-Tg-equg-T78319-Ab-1/ GM-Tg-equg-T78319-Ab-2Anti-Equine CD44 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T78319-Ab-1/ GM-Tg-hg-T78319-Ab-2; GM-Tg-rg-T78319-Ab-1/ GM-Tg-rg-T78319-Ab-2;
GM-Tg-mg-T78319-Ab-1/ GM-Tg-mg-T78319-Ab-2; GM-Tg-cynog-T78319-Ab-1/ GM-Tg-cynog-T78319-Ab-2;
GM-Tg-felg-T78319-Ab-1/ GM-Tg-felg-T78319-Ab-2; GM-Tg-cang-T78319-Ab-1/ GM-Tg-cang-T78319-Ab-2;
GM-Tg-bovg-T78319-Ab-1/ GM-Tg-bovg-T78319-Ab-2; GM-Tg-equg-T78319-Ab-1/ GM-Tg-equg-T78319-Ab-2
Products NameAnti-CD44 monoclonal antibody
Formatmab
Target NameCD44
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-CD44 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-INN-763Pre-Made Bivatuzumab Biosimilar, Whole Mab, Anti-Cd44 Antibody: Anti-CDW44/CSPG8/ECMR-III/HCELL/HUTCH-I/IN/LHR/MC56/MDU2/MDU3/MIC4/Pgp1 therapeutic antibody
    Target AntigenProducts DevelopingMulti-species CD44/ CDW44/ CSPG8 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMLP002663human CD44 Lentivirus plasmid
    ORF Viral VectorvGMLP002663human CD44 Lentivirus particle
    ORF Viral VectorpGMLPm004030mouse Cd44 Lentivirus plasmid
    ORF Viral VectorvGMLPm004030mouse Cd44 Lentivirus particle


    Target information

    Target IDGM-T78319
    Target NameCD44
    Gene ID960,12505,25406,717204,403939,101098744,281057,100034221
    Gene Symbol and SynonymsCD44,CD44A,CDW44,CSPG8,ECM-III,ECMR-III,H-CAM,HCELL,HERMES,Hermes-1,HUTCH-1,HUTCH-I,IN,LHR,Ly-24,MC56,MDU2,MDU3,METAA,MIC4,Pgp-1,Pgp1,RHAMM
    Uniprot AccessionP16070,P26051,Q28284,Q29423,Q05078
    Uniprot Entry NameCD44_HUMAN,CD44_RAT,CD44_CANLF,CD44_BOVIN,CD44_HORSE
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, Immuno-oncology Target, INN Index
    Diseasecolon cancer, Malignant neoplasm of bladder, Congenital occlusion of ureteropelvic junction, IgA glomerulonephritis, Lung cancer
    Gene EnsemblENSG00000026508
    Target ClassificationCheckpoint-Immuno Oncology

    The target: CD44, gene name: CD44, also named as CDW44, CSPG8, ECMR-III, HCELL, HUTCH-I, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1. The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.