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Anti-TPH1 monoclonal antibody
Pre-made anti-TPH1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to TPH1/TPH1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T78915-Ab-1/ GM-Tg-hg-T78915-Ab-2 | Anti-Human TPH1 monoclonal antibody | Human |
| GM-Tg-rg-T78915-Ab-1/ GM-Tg-rg-T78915-Ab-2 | Anti-Rat TPH1 monoclonal antibody | Rat |
| GM-Tg-mg-T78915-Ab-1/ GM-Tg-mg-T78915-Ab-2 | Anti-Mouse TPH1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T78915-Ab-1/ GM-Tg-cynog-T78915-Ab-2 | Anti-Cynomolgus/ Rhesus macaque TPH1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T78915-Ab-1/ GM-Tg-felg-T78915-Ab-2 | Anti-Feline TPH1 monoclonal antibody | Feline |
| GM-Tg-cang-T78915-Ab-1/ GM-Tg-cang-T78915-Ab-2 | Anti-Canine TPH1 monoclonal antibody | Canine |
| GM-Tg-bovg-T78915-Ab-1/ GM-Tg-bovg-T78915-Ab-2 | Anti-Bovine TPH1 monoclonal antibody | Bovine |
| GM-Tg-equg-T78915-Ab-1/ GM-Tg-equg-T78915-Ab-2 | Anti-Equine TPH1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T78915-Ab-1/ GM-Tg-hg-T78915-Ab-2; GM-Tg-rg-T78915-Ab-1/ GM-Tg-rg-T78915-Ab-2; GM-Tg-mg-T78915-Ab-1/ GM-Tg-mg-T78915-Ab-2; GM-Tg-cynog-T78915-Ab-1/ GM-Tg-cynog-T78915-Ab-2; GM-Tg-felg-T78915-Ab-1/ GM-Tg-felg-T78915-Ab-2; GM-Tg-cang-T78915-Ab-1/ GM-Tg-cang-T78915-Ab-2; GM-Tg-bovg-T78915-Ab-1/ GM-Tg-bovg-T78915-Ab-2; GM-Tg-equg-T78915-Ab-1/ GM-Tg-equg-T78915-Ab-2 |
| Products Name | Anti-TPH1 monoclonal antibody |
| Format | mab |
| Target Name | TPH1 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-TPH1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T78915-Ag-1 | Recombinant multi-species TPH1/ TPRH/ TRPH protein |
| ORF Viral Vector | pGMLP002012 | human TPH1 Lentivirus plasmid |
| ORF Viral Vector | pGMAP000485 | Human TPH1 Adenovirus plasmid |
| ORF Viral Vector | vGMLP002012 | human TPH1 Lentivirus particle |
| ORF Viral Vector | vGMAP000485 | Human TPH1 Adenovirus particle |
| ORF Viral Vector | pGMLPm002340 | mouse Tph1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002340 | mouse Tph1 Lentivirus particle |
Target information
| Target ID | GM-T78915 |
| Target Name | TPH1 |
| Gene ID | 7166,21990,24848,695363,611956,101098575,781941,100056614 |
| Gene Symbol and Synonyms | Tph,TPH1,TPRH,TRPH |
| Uniprot Accession | P17752,P09810 |
| Uniprot Entry Name | TPH1_HUMAN,TPH1_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target, Immuno-oncology Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000129167 |
| Target Classification | Checkpoint-Immuno Oncology |
The target: TPH1, gene name: TPH1, also named as TPRH, TRPH. This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.[provided by RefSeq, Apr 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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