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Anti-THRA monoclonal antibody
Pre-made anti-THRA monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to THRA/THRA products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T79591-Ab-1/ GM-Tg-hg-T79591-Ab-2 | Anti-Human THRA monoclonal antibody | Human |
| GM-Tg-rg-T79591-Ab-1/ GM-Tg-rg-T79591-Ab-2 | Anti-Rat THRA monoclonal antibody | Rat |
| GM-Tg-mg-T79591-Ab-1/ GM-Tg-mg-T79591-Ab-2 | Anti-Mouse THRA monoclonal antibody | Mouse |
| GM-Tg-cynog-T79591-Ab-1/ GM-Tg-cynog-T79591-Ab-2 | Anti-Cynomolgus/ Rhesus macaque THRA monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T79591-Ab-1/ GM-Tg-felg-T79591-Ab-2 | Anti-Feline THRA monoclonal antibody | Feline |
| GM-Tg-cang-T79591-Ab-1/ GM-Tg-cang-T79591-Ab-2 | Anti-Canine THRA monoclonal antibody | Canine |
| GM-Tg-bovg-T79591-Ab-1/ GM-Tg-bovg-T79591-Ab-2 | Anti-Bovine THRA monoclonal antibody | Bovine |
| GM-Tg-equg-T79591-Ab-1/ GM-Tg-equg-T79591-Ab-2 | Anti-Equine THRA monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T79591-Ab-1/ GM-Tg-hg-T79591-Ab-2; GM-Tg-rg-T79591-Ab-1/ GM-Tg-rg-T79591-Ab-2; GM-Tg-mg-T79591-Ab-1/ GM-Tg-mg-T79591-Ab-2; GM-Tg-cynog-T79591-Ab-1/ GM-Tg-cynog-T79591-Ab-2; GM-Tg-felg-T79591-Ab-1/ GM-Tg-felg-T79591-Ab-2; GM-Tg-cang-T79591-Ab-1/ GM-Tg-cang-T79591-Ab-2; GM-Tg-bovg-T79591-Ab-1/ GM-Tg-bovg-T79591-Ab-2; GM-Tg-equg-T79591-Ab-1/ GM-Tg-equg-T79591-Ab-2 |
| Products Name | Anti-THRA monoclonal antibody |
| Format | mab |
| Target Name | THRA |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-THRA monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T79591-Ag-1 | Recombinant multi-species THA/ THRA/ AR7 protein |
| ORF Viral Vector | vGMAP000182 | Human THRA Adenovirus particle |
| ORF Viral Vector | pGMAP000182 | Human THRA Adenovirus plasmid |
| ORF Viral Vector | pGMLPm002106 | mouse Thra Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002106 | mouse Thra Lentivirus particle |
Target information
| Target ID | GM-T79591 |
| Target Name | THRA |
| Gene ID | 7067,21833,81812,699650,403601,101095056,532621,100054511 |
| Gene Symbol and Synonyms | 6430529J03Rik,AR7,c-erbA,c-ERBA-1,c-erbA-alpha,c-erbAalpha,CHNG6,EAR7,ERB-T-1,ERBA,ERBA1,NR1A1,NR1D1,Rvr,T3Ralpha,T3R[a],THRA,THRA1,THRA2,THRalpha,THRalpha1,THRalpha2,TRalpha,TRalpha1,TRalpha2 |
| Uniprot Accession | P10827,P63059 |
| Uniprot Entry Name | THA_HUMAN,THA_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Prostate Cancer |
| Gene Ensembl | ENSG00000126351 |
| Target Classification | Nuclear Receptors |
The target: THRA, gene name: THRA, also named as AR7, CHNG6, EAR7, ERB-T-1, ERBA, ERBA1, NR1A11, THRA2, c-ERBA-1, THRA. The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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