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Anti-CALR/ CRT/ HEL-S-99n functional antibody
Anti-CALR/ CRT/ HEL-S-99n functional antibody for cell culture, ELISA & in-vivo assay
Go to CALR/CALR products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T79821-Ab-1/ GM-Tg-hg-T79821-Ab-2 | Anti-Human CALR monoclonal antibody | Human |
| GM-Tg-rg-T79821-Ab-1/ GM-Tg-rg-T79821-Ab-2 | Anti-Rat CALR monoclonal antibody | Rat |
| GM-Tg-mg-T79821-Ab-1/ GM-Tg-mg-T79821-Ab-2 | Anti-Mouse CALR monoclonal antibody | Mouse |
| GM-Tg-cynog-T79821-Ab-1/ GM-Tg-cynog-T79821-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CALR monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T79821-Ab-1/ GM-Tg-felg-T79821-Ab-2 | Anti-Feline CALR monoclonal antibody | Feline |
| GM-Tg-cang-T79821-Ab-1/ GM-Tg-cang-T79821-Ab-2 | Anti-Canine CALR monoclonal antibody | Canine |
| GM-Tg-bovg-T79821-Ab-1/ GM-Tg-bovg-T79821-Ab-2 | Anti-Bovine CALR monoclonal antibody | Bovine |
| GM-Tg-equg-T79821-Ab-1/ GM-Tg-equg-T79821-Ab-2 | Anti-Equine CALR monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T79821-Ab-1/ GM-Tg-hg-T79821-Ab-2; GM-Tg-rg-T79821-Ab-1/ GM-Tg-rg-T79821-Ab-2; GM-Tg-mg-T79821-Ab-1/ GM-Tg-mg-T79821-Ab-2; GM-Tg-cynog-T79821-Ab-1/ GM-Tg-cynog-T79821-Ab-2; GM-Tg-felg-T79821-Ab-1/ GM-Tg-felg-T79821-Ab-2; GM-Tg-cang-T79821-Ab-1/ GM-Tg-cang-T79821-Ab-2; GM-Tg-bovg-T79821-Ab-1/ GM-Tg-bovg-T79821-Ab-2; GM-Tg-equg-T79821-Ab-1/ GM-Tg-equg-T79821-Ab-2 |
| Products Name | Anti-CALR monoclonal antibody |
| Format | mab |
| Target Name | CALR |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CALR benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T79821-Ag-1 | Recombinant multi-species CALR/ CRT/ HEL-S-99n protein |
| ORF Viral Vector | pGMLP000141 | human CALR Lentivirus plasmid |
| ORF Viral Vector | pGMAP000540 | human CALR Adenovirus plasmid |
| ORF Viral Vector | vGMLP000141 | human CALR Lentivirus particle |
| ORF Viral Vector | vGMAP000540 | human CALR Adenovirus particle |
| ORF Viral Vector | pGMAD000312 | rat Calr Adenovirus plasmid |
| ORF Viral Vector | pGMLPm001791 | mouse Calr Lentivirus plasmid |
| ORF Viral Vector | vGMAD000312 | rat Calr Adenovirus particle |
| ORF Viral Vector | vGMLPm001791 | mouse Calr Lentivirus particle |
Target information
| Target ID | GM-T79821 |
| Target Name | CALR |
| Gene ID | 811,12317,64202,716910,476694,101087384,281036,100064107 |
| Gene Symbol and Synonyms | CALR,CALR1,Calregulin,cC1qR,CRP55,CRT,ERp60,HACBP,HEL-S-99n,RO,SSA |
| Uniprot Accession | P27797,P18418,P28490,P52193 |
| Uniprot Entry Name | CALR_HUMAN,CALR_RAT,CALR_CANLF,CALR_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, Immuno-oncology Target |
| Disease | Prostate Cancer, Malignant neoplasm of bladder |
| Gene Ensembl | ENSG00000179218 |
| Target Classification | Checkpoint-Immuno Oncology |
The target: CALR, gene name: CALR, also named as CRT, HEL-S-99n, RO, SSA, cC1qR. Calreticulin is a highly conserved chaperone protein which resides primarily in the endoplasmic reticulum, and is involved in a variety of cellular processes, among them, cell adhesion. Additionally, it functions in protein folding quality control and calcium homeostasis. Calreticulin is also found in the nucleus, suggesting that it may have a role in transcription regulation. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin. Recurrent mutations in calreticulin have been linked to various neoplasms, including the myeloproliferative type.[provided by RefSeq, May 2020].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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