Anti-AVR2B/ ACVR2B/ ACTRIIB monoclonal antibody

Anti-AVR2B/ ACVR2B/ ACTRIIB antibody for FACS & in-vivo assay

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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Size： 1mg | 10mg | 100mg

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Target information

The target: ACVR2B, gene name: ACVR2B, also named as ACTRIIB, ActR-IIB, HTX4. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq, Jul 2008].

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