- • Up to 20% off your first purchase
- • Bulk quantities available
- • Citation Reward application
Sample Application
- Animal health test
- In-vitro diagnostics
- Food & Feed Safety
- Environmental Safety
- New drug discovery
Supports
- Talk to our Expert:
[email protected] -
Talk to our sales:
[email protected]
Protocol Library Download
 |
 |
Anti-KLF4 monoclonal antibody
Pre-made anti-KLF4 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to KLF4/KLF4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T81916-Ab-1/ GM-Tg-hg-T81916-Ab-2 | Anti-Human KLF4 monoclonal antibody | Human |
| GM-Tg-rg-T81916-Ab-1/ GM-Tg-rg-T81916-Ab-2 | Anti-Rat KLF4 monoclonal antibody | Rat |
| GM-Tg-mg-T81916-Ab-1/ GM-Tg-mg-T81916-Ab-2 | Anti-Mouse KLF4 monoclonal antibody | Mouse |
| GM-Tg-cynog-T81916-Ab-1/ GM-Tg-cynog-T81916-Ab-2 | Anti-Cynomolgus/ Rhesus macaque KLF4 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T81916-Ab-1/ GM-Tg-felg-T81916-Ab-2 | Anti-Feline KLF4 monoclonal antibody | Feline |
| GM-Tg-cang-T81916-Ab-1/ GM-Tg-cang-T81916-Ab-2 | Anti-Canine KLF4 monoclonal antibody | Canine |
| GM-Tg-bovg-T81916-Ab-1/ GM-Tg-bovg-T81916-Ab-2 | Anti-Bovine KLF4 monoclonal antibody | Bovine |
| GM-Tg-equg-T81916-Ab-1/ GM-Tg-equg-T81916-Ab-2 | Anti-Equine KLF4 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T81916-Ab-1/ GM-Tg-hg-T81916-Ab-2; GM-Tg-rg-T81916-Ab-1/ GM-Tg-rg-T81916-Ab-2; GM-Tg-mg-T81916-Ab-1/ GM-Tg-mg-T81916-Ab-2; GM-Tg-cynog-T81916-Ab-1/ GM-Tg-cynog-T81916-Ab-2; GM-Tg-felg-T81916-Ab-1/ GM-Tg-felg-T81916-Ab-2; GM-Tg-cang-T81916-Ab-1/ GM-Tg-cang-T81916-Ab-2; GM-Tg-bovg-T81916-Ab-1/ GM-Tg-bovg-T81916-Ab-2; GM-Tg-equg-T81916-Ab-1/ GM-Tg-equg-T81916-Ab-2 |
| Products Name | Anti-KLF4 monoclonal antibody |
| Format | mab |
| Target Name | KLF4 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-KLF4 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T81916-Ag-1 | Recombinant multi-species KLF4/ EZF/ GKLF protein |
| ORF Viral Vector | vGMAD000164 | human KLF4 Adenovirus particle |
| ORF Viral Vector | vGMLV000247 | human KLF4 Lentivirus particle |
| ORF Viral Vector | pGMLV000247 | human KLF4 Lentivirus plasmid |
| ORF Viral Vector | pGMAD000164 | human KLF4 Adenovirus plasmid |
| ORF Viral Vector | pGMAD000237 | mouse Klf4 Adenovirus plasmid |
| ORF Viral Vector | pGMAD000361 | rat Klf4 Adenovirus plasmid |
| ORF Viral Vector | pGMAAV000090 | rat Klf4 AAV plasmid |
| ORF Viral Vector | pGMAAV000259 | house mouse Klf4 AAV plasmid |
| ORF Viral Vector | vGMAD000237 | mouse Klf4 Adenovirus particle |
| ORF Viral Vector | vGMAD000361 | rat Klf4 Adenovirus particle |
| ORF Viral Vector | vGMAAV000090 | rat Klf4 AAV particle |
| ORF Viral Vector | vGMAAV000259 | house mouse Klf4 AAV particle |
Target information
| Target ID | GM-T81916 |
| Target Name | KLF4 |
| Gene ID | 9314,16600,114505,711169,481657,100379626,520842,100054047 |
| Gene Symbol and Synonyms | EZF,GKLF,KLF4,Zie |
| Uniprot Accession | O43474 |
| Uniprot Entry Name | KLF4_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000136826 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: KLF4, gene name: KLF4, also named as EZF, GKLF. This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is required for normal development of the barrier function of skin. The encoded protein is thought to control the G1-to-S transition of the cell cycle following DNA damage by mediating the tumor suppressor gene p53. Mice lacking this gene have a normal appearance but lose weight rapidly, and die shortly after birth due to fluid evaporation resulting from compromised epidermal barrier function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
Facebook
LinkedIn
Twitter
