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Anti-CNTF monoclonal antibody
Pre-made anti-CNTF monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to CNTF/CNTF products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T83192-Ab-1/ GM-Tg-hg-T83192-Ab-2 | Anti-Human CNTF monoclonal antibody | Human |
| GM-Tg-rg-T83192-Ab-1/ GM-Tg-rg-T83192-Ab-2 | Anti-Rat CNTF monoclonal antibody | Rat |
| GM-Tg-mg-T83192-Ab-1/ GM-Tg-mg-T83192-Ab-2 | Anti-Mouse CNTF monoclonal antibody | Mouse |
| GM-Tg-cynog-T83192-Ab-1/ GM-Tg-cynog-T83192-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CNTF monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T83192-Ab-1/ GM-Tg-felg-T83192-Ab-2 | Anti-Feline CNTF monoclonal antibody | Feline |
| GM-Tg-cang-T83192-Ab-1/ GM-Tg-cang-T83192-Ab-2 | Anti-Canine CNTF monoclonal antibody | Canine |
| GM-Tg-bovg-T83192-Ab-1/ GM-Tg-bovg-T83192-Ab-2 | Anti-Bovine CNTF monoclonal antibody | Bovine |
| GM-Tg-equg-T83192-Ab-1/ GM-Tg-equg-T83192-Ab-2 | Anti-Equine CNTF monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T83192-Ab-1/ GM-Tg-hg-T83192-Ab-2; GM-Tg-rg-T83192-Ab-1/ GM-Tg-rg-T83192-Ab-2; GM-Tg-mg-T83192-Ab-1/ GM-Tg-mg-T83192-Ab-2; GM-Tg-cynog-T83192-Ab-1/ GM-Tg-cynog-T83192-Ab-2; GM-Tg-felg-T83192-Ab-1/ GM-Tg-felg-T83192-Ab-2; GM-Tg-cang-T83192-Ab-1/ GM-Tg-cang-T83192-Ab-2; GM-Tg-bovg-T83192-Ab-1/ GM-Tg-bovg-T83192-Ab-2; GM-Tg-equg-T83192-Ab-1/ GM-Tg-equg-T83192-Ab-2 |
| Products Name | Anti-CNTF monoclonal antibody |
| Format | mab |
| Target Name | CNTF |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-CNTF monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T83192-Ag-1 | Recombinant multi-species CNTF/ HCNTF protein |
| Cytokine | GM-Tg-g-T83192-Ag-1 | ciliary neurotrophic factor (CNTF) protein |
| ORF Viral Vector | pGMAP000377 | Human CNTF Adenovirus plasmid |
| ORF Viral Vector | vGMLP000479 | human CNTF Lentivirus particle |
| ORF Viral Vector | pGMLP000479 | human CNTF Lentivirus plasmid |
| ORF Viral Vector | vGMAP000377 | Human CNTF Adenovirus particle |
| ORF Viral Vector | pGMLV000127 | rat Cntf Lentivirus plasmid |
| ORF Viral Vector | pGMLPm000009 | mouse Cntf Lentivirus plasmid |
| ORF Viral Vector | vGMLV000127 | rat Cntf Lentivirus particle |
| ORF Viral Vector | vGMLPm000009 | mouse Cntf Lentivirus particle |
Target information
| Target ID | GM-T83192 |
| Target Name | CNTF |
| Gene ID | 1270,12803,25707,701907,483464,101097592,100848228,100629778 |
| Gene Symbol and Synonyms | CNTF,HCNTF |
| Uniprot Accession | P26441,P20294 |
| Uniprot Entry Name | CNTF_HUMAN,CNTF_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target, Cytokine Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000242689 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: CNTF, gene name: CNTF, also named as HCNTF. The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of the upstream ZFP91 gene and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. [provided by RefSeq, Oct 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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