Anti-HGF/ DFNB39/ F-TCFB functional antibody

Anti-HGF/ DFNB39/ F-TCFB functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to HGF/HGF products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T83797-Ab-1/ GM-Tg-hg-T83797-Ab-2Anti-Human HGF monoclonal antibodyHuman
GM-Tg-rg-T83797-Ab-1/ GM-Tg-rg-T83797-Ab-2Anti-Rat HGF monoclonal antibodyRat
GM-Tg-mg-T83797-Ab-1/ GM-Tg-mg-T83797-Ab-2Anti-Mouse HGF monoclonal antibodyMouse
GM-Tg-cynog-T83797-Ab-1/ GM-Tg-cynog-T83797-Ab-2Anti-Cynomolgus/ Rhesus macaque HGF monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T83797-Ab-1/ GM-Tg-felg-T83797-Ab-2Anti-Feline HGF monoclonal antibodyFeline
GM-Tg-cang-T83797-Ab-1/ GM-Tg-cang-T83797-Ab-2Anti-Canine HGF monoclonal antibodyCanine
GM-Tg-bovg-T83797-Ab-1/ GM-Tg-bovg-T83797-Ab-2Anti-Bovine HGF monoclonal antibodyBovine
GM-Tg-equg-T83797-Ab-1/ GM-Tg-equg-T83797-Ab-2Anti-Equine HGF monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T83797-Ab-1/ GM-Tg-hg-T83797-Ab-2; GM-Tg-rg-T83797-Ab-1/ GM-Tg-rg-T83797-Ab-2;
GM-Tg-mg-T83797-Ab-1/ GM-Tg-mg-T83797-Ab-2; GM-Tg-cynog-T83797-Ab-1/ GM-Tg-cynog-T83797-Ab-2;
GM-Tg-felg-T83797-Ab-1/ GM-Tg-felg-T83797-Ab-2; GM-Tg-cang-T83797-Ab-1/ GM-Tg-cang-T83797-Ab-2;
GM-Tg-bovg-T83797-Ab-1/ GM-Tg-bovg-T83797-Ab-2; GM-Tg-equg-T83797-Ab-1/ GM-Tg-equg-T83797-Ab-2
Products NameAnti-HGF monoclonal antibody
Formatmab
Target NameHGF
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-HGF benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-ab-212Pre-Made Ficlatuzumab biosimilar, Whole mAb, Anti-HGF Antibody: Anti-DFNB39/F-TCF/HPTA/SF therapeutic antibody
    BiosimilarGMP-Bios-ab-483Pre-Made Rilotumumab biosimilar, Whole mAb, Anti-HGF Antibody: Anti-DFNB39/F-TCF/HPTA/SF therapeutic antibody
    Target AntigenGM-Tg-g-T83797-Ag-1Recombinant multi-species HGF/ DFNB39/ F-TCFB protein
    CytokineGM-Tg-g-T83797-Ag-1hepatocyte growth factor (HGF) protein
    ORF Viral VectorvGMLV000683human HGF Lentivirus particle
    ORF Viral VectorpGMLV000683human HGF Lentivirus plasmid
    ORF Viral VectorpGMLV000432human HGF Lentivirus plasmid
    ORF Viral VectorvGMLV000432human HGF Lentivirus particle
    ORF Viral VectorpGMLV000677Norway rat hgf Lentivirus plasmid
    ORF Viral VectorvGMLV000677Norway rat hgf Lentivirus particle


    Target information

    Target IDGM-T83797
    Target NameHGF
    Gene ID3082,15234,24446,708316,403441,493705,282879,100049848
    Gene Symbol and SynonymsC230052L06Rik,DFNB39,F-TCF,HGF,HGF/SF,HGFB,HPTA,NK1,NK2,SF,SF/HGF
    Uniprot AccessionP14210,P17945,Q867B7,Q9BH09,Q76BS1
    Uniprot Entry NameHGF_HUMAN,HGF_RAT,HGF_FELCA,HGF_CANLF,HGF_BOVIN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    CategoryTherapeutics Target, Immuno-oncology Target, INN Index, Cytokine Target
    DiseaseLiver Cancer, breast cancer
    Gene EnsemblENSG00000019991
    Target ClassificationCheckpoint-Immuno Oncology

    The target: HGF, gene name: HGF, also named as DFNB39, F-TCFB, HPTA, SF, HGF. This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in this gene are associated with nonsyndromic hearing loss. [provided by RefSeq, Nov 2015].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.