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Anti-CLCF1/ BSF-3/ BSF3 functional antibody
Anti-CLCF1/ BSF-3/ BSF3 functional antibody for cell culture, ELISA & in-vivo assay
Go to CLCF1/CLCF1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T84019-Ab-1/ GM-Tg-hg-T84019-Ab-2 | Anti-Human CLCF1 monoclonal antibody | Human |
| GM-Tg-rg-T84019-Ab-1/ GM-Tg-rg-T84019-Ab-2 | Anti-Rat CLCF1 monoclonal antibody | Rat |
| GM-Tg-mg-T84019-Ab-1/ GM-Tg-mg-T84019-Ab-2 | Anti-Mouse CLCF1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T84019-Ab-1/ GM-Tg-cynog-T84019-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CLCF1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T84019-Ab-1/ GM-Tg-felg-T84019-Ab-2 | Anti-Feline CLCF1 monoclonal antibody | Feline |
| GM-Tg-cang-T84019-Ab-1/ GM-Tg-cang-T84019-Ab-2 | Anti-Canine CLCF1 monoclonal antibody | Canine |
| GM-Tg-bovg-T84019-Ab-1/ GM-Tg-bovg-T84019-Ab-2 | Anti-Bovine CLCF1 monoclonal antibody | Bovine |
| GM-Tg-equg-T84019-Ab-1/ GM-Tg-equg-T84019-Ab-2 | Anti-Equine CLCF1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T84019-Ab-1/ GM-Tg-hg-T84019-Ab-2; GM-Tg-rg-T84019-Ab-1/ GM-Tg-rg-T84019-Ab-2; GM-Tg-mg-T84019-Ab-1/ GM-Tg-mg-T84019-Ab-2; GM-Tg-cynog-T84019-Ab-1/ GM-Tg-cynog-T84019-Ab-2; GM-Tg-felg-T84019-Ab-1/ GM-Tg-felg-T84019-Ab-2; GM-Tg-cang-T84019-Ab-1/ GM-Tg-cang-T84019-Ab-2; GM-Tg-bovg-T84019-Ab-1/ GM-Tg-bovg-T84019-Ab-2; GM-Tg-equg-T84019-Ab-1/ GM-Tg-equg-T84019-Ab-2 |
| Products Name | Anti-CLCF1 monoclonal antibody |
| Format | mab |
| Target Name | CLCF1 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CLCF1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T84019-Ag-1 | Recombinant multi-species CLCF1/ BSF-3/ BSF3 protein |
| Cytokine | GM-Tg-g-T84019-Ag-1 | cardiotrophin-like cytokine factor 1 (CLCF1) protein |
| ORF Viral Vector | vGMLP003461 | human CLCF1 Lentivirus particle |
| ORF Viral Vector | pGMLP003461 | human CLCF1 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm001907 | mouse Clcf1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001907 | mouse Clcf1 Lentivirus particle |
Target information
| Target ID | GM-T84019 |
| Target Name | CLCF1 |
| Gene ID | 23529,56708,365395,712554,483697,101101338,100336481,100146651 |
| Gene Symbol and Synonyms | BSF-3,BSF3,CISS2,CLC,CLCF1,NNT-1,NNT1,NR6 |
| Uniprot Accession | Q9UBD9 |
| Uniprot Entry Name | CLCF1_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000175505 |
| Target Classification | N/A |
The target: CLCF1, gene name: CLCF1, also named as BSF-3, BSF3, CISS2, CLC, NNT-1, NNT1, NR6. This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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