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Anti-CA2D1/ CACNA2D1/ CACNA2 functional antibody
Anti-CA2D1/ CACNA2D1/ CACNA2 functional antibody for cell culture, ELISA & in-vivo assay
Go to CACNA2D1/CACNA2D1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T84316-Ab-1/ GM-Tg-hg-T84316-Ab-2 | Anti-Human CACNA2D1 monoclonal antibody | Human |
| GM-Tg-rg-T84316-Ab-1/ GM-Tg-rg-T84316-Ab-2 | Anti-Rat CACNA2D1 monoclonal antibody | Rat |
| GM-Tg-mg-T84316-Ab-1/ GM-Tg-mg-T84316-Ab-2 | Anti-Mouse CACNA2D1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T84316-Ab-1/ GM-Tg-cynog-T84316-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CACNA2D1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T84316-Ab-1/ GM-Tg-felg-T84316-Ab-2 | Anti-Feline CACNA2D1 monoclonal antibody | Feline |
| GM-Tg-cang-T84316-Ab-1/ GM-Tg-cang-T84316-Ab-2 | Anti-Canine CACNA2D1 monoclonal antibody | Canine |
| GM-Tg-bovg-T84316-Ab-1/ GM-Tg-bovg-T84316-Ab-2 | Anti-Bovine CACNA2D1 monoclonal antibody | Bovine |
| GM-Tg-equg-T84316-Ab-1/ GM-Tg-equg-T84316-Ab-2 | Anti-Equine CACNA2D1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T84316-Ab-1/ GM-Tg-hg-T84316-Ab-2; GM-Tg-rg-T84316-Ab-1/ GM-Tg-rg-T84316-Ab-2; GM-Tg-mg-T84316-Ab-1/ GM-Tg-mg-T84316-Ab-2; GM-Tg-cynog-T84316-Ab-1/ GM-Tg-cynog-T84316-Ab-2; GM-Tg-felg-T84316-Ab-1/ GM-Tg-felg-T84316-Ab-2; GM-Tg-cang-T84316-Ab-1/ GM-Tg-cang-T84316-Ab-2; GM-Tg-bovg-T84316-Ab-1/ GM-Tg-bovg-T84316-Ab-2; GM-Tg-equg-T84316-Ab-1/ GM-Tg-equg-T84316-Ab-2 |
| Products Name | Anti-CACNA2D1 monoclonal antibody |
| Format | mab |
| Target Name | CACNA2D1 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CACNA2D1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T84316-Ag-1 | Recombinant multi-species CA2D1/ CACNA2D1/ CACNA2 protein |
Target information
| Target ID | GM-T84316 |
| Target Name | CACNA2D1 |
| Gene ID | 781,12293,25399,708215,610342,101099450,282608,100057533 |
| Gene Symbol and Synonyms | Ca(v)alpha2delta1,CACNA2,CACNA2D1,CACNL2A,CCHL2A,CCHLA2,DEE110,DHSCCA,LINC01112,lncRNA-N3 |
| Uniprot Accession | P54289,P54290 |
| Uniprot Entry Name | CA2D1_HUMAN,CA2D1_RAT |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000153956 |
| Target Classification | N/A |
The target: CACNA2D1, gene name: CACNA2D1, also named as CACNA2, CACNL2A, CCHL2A, LINC01112, lncRNA-N3. The preproprotein encoded by this gene is cleaved into multiple chains that comprise the alpha-2 and delta subunits of the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. Mutations in this gene can cause cardiac deficiencies, including Brugada syndrome and short QT syndrome. Alternate splicing results in multiple transcript variants, some of which may lack the delta subunit portion. [provided by RefSeq, Nov 2014].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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