Anti-TXNRD1 monoclonal antibody
Pre-made anti-TXNRD1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to TXNRD1/TXNRD1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T84581-Ab-1/ GM-Tg-hg-T84581-Ab-2 | Anti-Human TXNRD1 monoclonal antibody | Human |
GM-Tg-rg-T84581-Ab-1/ GM-Tg-rg-T84581-Ab-2 | Anti-Rat TXNRD1 monoclonal antibody | Rat |
GM-Tg-mg-T84581-Ab-1/ GM-Tg-mg-T84581-Ab-2 | Anti-Mouse TXNRD1 monoclonal antibody | Mouse |
GM-Tg-cynog-T84581-Ab-1/ GM-Tg-cynog-T84581-Ab-2 | Anti-Cynomolgus/ Rhesus macaque TXNRD1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T84581-Ab-1/ GM-Tg-felg-T84581-Ab-2 | Anti-Feline TXNRD1 monoclonal antibody | Feline |
GM-Tg-cang-T84581-Ab-1/ GM-Tg-cang-T84581-Ab-2 | Anti-Canine TXNRD1 monoclonal antibody | Canine |
GM-Tg-bovg-T84581-Ab-1/ GM-Tg-bovg-T84581-Ab-2 | Anti-Bovine TXNRD1 monoclonal antibody | Bovine |
GM-Tg-equg-T84581-Ab-1/ GM-Tg-equg-T84581-Ab-2 | Anti-Equine TXNRD1 monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T84581-Ab-1/ GM-Tg-hg-T84581-Ab-2; GM-Tg-rg-T84581-Ab-1/ GM-Tg-rg-T84581-Ab-2; GM-Tg-mg-T84581-Ab-1/ GM-Tg-mg-T84581-Ab-2; GM-Tg-cynog-T84581-Ab-1/ GM-Tg-cynog-T84581-Ab-2; GM-Tg-felg-T84581-Ab-1/ GM-Tg-felg-T84581-Ab-2; GM-Tg-cang-T84581-Ab-1/ GM-Tg-cang-T84581-Ab-2; GM-Tg-bovg-T84581-Ab-1/ GM-Tg-bovg-T84581-Ab-2; GM-Tg-equg-T84581-Ab-1/ GM-Tg-equg-T84581-Ab-2 |
Products Name | Anti-TXNRD1 monoclonal antibody |
Format | mab |
Target Name | TXNRD1 |
Protein Sub-location | Introcelluar Protein |
Category of antibody | Therapeutics Target antibody, Diagnostic target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
Tag | Fc |
Products description | Pre-made anti-TXNRD1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation | Lyophilized from sterile PBS, PH 7.4 |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | GM-Tg-g-T84581-Ag-1 | Recombinant multi-species TRXR1/ TXNRD1/ GRIM-12 protein |
ORF Viral Vector | vGMLP003303 | human TXNRD1 Lentivirus particle |
ORF Viral Vector | pGMLP003303 | human TXNRD1 Lentivirus plasmid |
Target information
Target ID | GM-T84581 |
Target Name | TXNRD1 |
Gene ID | 7296,50493,58819,701062,474536,101085222,282388 |
Gene Symbol and Synonyms | GRIM-12,TR,TR1,TRXR1,TXNR,TXNRD1 |
Uniprot Accession | Q16881,O89049,O62768 |
Uniprot Entry Name | TRXR1_HUMAN,TRXR1_RAT,TRXR1_BOVIN |
Protein Sub-location | Introcelluar Protein |
Category | Therapeutics Target, Diagnostics Biomarker |
Disease | Malignant neoplasm of bladder, IgA glomerulonephritis, leukemia |
Gene Ensembl | ENSG00000198431 |
Target Classification | N/A |
The target: TXNRD1, gene name: TXNRD1, also named as GRIM-12, TR, TR1, TRXR1, TXNR. The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes an ubiquitously expressed, cytosolic form of TrxR, which functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing, primarily at the 5' end, results in transcript variants encoding same or different isoforms, including a glutaredoxin-containing isoform that is predominantly expressed in testis. [provided by RefSeq, May 2017].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.