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Anti-NGF/ Beta-NGF/ HSAN5B functional antibody
Anti-NGF/ Beta-NGF/ HSAN5B functional antibody for cell culture, ELISA & in-vivo assay
Go to NGF/NGF products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T85670-Ab-1/ GM-Tg-hg-T85670-Ab-2 | Anti-Human NGF monoclonal antibody | Human |
| GM-Tg-rg-T85670-Ab-1/ GM-Tg-rg-T85670-Ab-2 | Anti-Rat NGF monoclonal antibody | Rat |
| GM-Tg-mg-T85670-Ab-1/ GM-Tg-mg-T85670-Ab-2 | Anti-Mouse NGF monoclonal antibody | Mouse |
| GM-Tg-cynog-T85670-Ab-1/ GM-Tg-cynog-T85670-Ab-2 | Anti-Cynomolgus/ Rhesus macaque NGF monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T85670-Ab-1/ GM-Tg-felg-T85670-Ab-2 | Anti-Feline NGF monoclonal antibody | Feline |
| GM-Tg-cang-T85670-Ab-1/ GM-Tg-cang-T85670-Ab-2 | Anti-Canine NGF monoclonal antibody | Canine |
| GM-Tg-bovg-T85670-Ab-1/ GM-Tg-bovg-T85670-Ab-2 | Anti-Bovine NGF monoclonal antibody | Bovine |
| GM-Tg-equg-T85670-Ab-1/ GM-Tg-equg-T85670-Ab-2 | Anti-Equine NGF monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T85670-Ab-1/ GM-Tg-hg-T85670-Ab-2; GM-Tg-rg-T85670-Ab-1/ GM-Tg-rg-T85670-Ab-2; GM-Tg-mg-T85670-Ab-1/ GM-Tg-mg-T85670-Ab-2; GM-Tg-cynog-T85670-Ab-1/ GM-Tg-cynog-T85670-Ab-2; GM-Tg-felg-T85670-Ab-1/ GM-Tg-felg-T85670-Ab-2; GM-Tg-cang-T85670-Ab-1/ GM-Tg-cang-T85670-Ab-2; GM-Tg-bovg-T85670-Ab-1/ GM-Tg-bovg-T85670-Ab-2; GM-Tg-equg-T85670-Ab-1/ GM-Tg-equg-T85670-Ab-2 |
| Products Name | Anti-NGF monoclonal antibody |
| Format | mab |
| Target Name | NGF |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-NGF benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T85670-Ag-1 | Recombinant multi-species NGF/ Beta-NGF/ HSAN5B protein |
| Cytokine | GM-Tg-g-T85670-Ag-1 | Nerve growth factor (NGF) protein |
| ORF Viral Vector | vGMLV000284 | human NGF Lentivirus particle |
| ORF Viral Vector | pGMLV000284 | human NGF Lentivirus plasmid |
| ORF Viral Vector | pGMAAV000148 | rat Ngf AAV plasmid |
| ORF Viral Vector | pGMAAV000279 | house mouse Ngf AAV plasmid |
| ORF Viral Vector | pGMLPm000818 | mouse Ngf Lentivirus plasmid |
| ORF Viral Vector | vGMAAV000148 | rat Ngf AAV particle |
| ORF Viral Vector | vGMAAV000279 | house mouse Ngf AAV particle |
| ORF Viral Vector | vGMLPm000818 | mouse Ngf Lentivirus particle |
Target information
| Target ID | GM-T85670 |
| Target Name | NGF |
| Gene ID | 4803,18049,310738,711681,403402,100144611,281350,100065669 |
| Gene Symbol and Synonyms | Beta-NGF,HSAN5,NGF,NGFB |
| Uniprot Accession | P01138,P25427,P13600 |
| Uniprot Entry Name | NGF_HUMAN,NGF_RAT,NGF_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, Cytokine Target |
| Disease | Overactive bladder, Bladder Pain, Interstitial cystitis (chronic), Urinary Tract Infection, Neurological deficits - peripheral neuropathy, Parkinson's Disease |
| Gene Ensembl | ENSG00000134259 |
| Target Classification | N/A |
The target: NGF, gene name: NGF, also named as Beta-NGF, HSAN5B, NGF. This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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