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Anti-LRP5/ BMND1/ EVR1 monoclonal antibody
Anti-LRP5/ BMND1/ EVR1 antibody for FACS & in-vivo assay
Go to LRP5/LRP5 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T86072-Ab-1/ GM-Tg-hg-T86072-Ab-2 | Anti-Human LRP5 monoclonal antibody | Human |
| GM-Tg-rg-T86072-Ab-1/ GM-Tg-rg-T86072-Ab-2 | Anti-Rat LRP5 monoclonal antibody | Rat |
| GM-Tg-mg-T86072-Ab-1/ GM-Tg-mg-T86072-Ab-2 | Anti-Mouse LRP5 monoclonal antibody | Mouse |
| GM-Tg-cynog-T86072-Ab-1/ GM-Tg-cynog-T86072-Ab-2 | Anti-Cynomolgus/ Rhesus macaque LRP5 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T86072-Ab-1/ GM-Tg-felg-T86072-Ab-2 | Anti-Feline LRP5 monoclonal antibody | Feline |
| GM-Tg-cang-T86072-Ab-1/ GM-Tg-cang-T86072-Ab-2 | Anti-Canine LRP5 monoclonal antibody | Canine |
| GM-Tg-bovg-T86072-Ab-1/ GM-Tg-bovg-T86072-Ab-2 | Anti-Bovine LRP5 monoclonal antibody | Bovine |
| GM-Tg-equg-T86072-Ab-1/ GM-Tg-equg-T86072-Ab-2 | Anti-Equine LRP5 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T86072-Ab-1/ GM-Tg-hg-T86072-Ab-2; GM-Tg-rg-T86072-Ab-1/ GM-Tg-rg-T86072-Ab-2; GM-Tg-mg-T86072-Ab-1/ GM-Tg-mg-T86072-Ab-2; GM-Tg-cynog-T86072-Ab-1/ GM-Tg-cynog-T86072-Ab-2; GM-Tg-felg-T86072-Ab-1/ GM-Tg-felg-T86072-Ab-2; GM-Tg-cang-T86072-Ab-1/ GM-Tg-cang-T86072-Ab-2; GM-Tg-bovg-T86072-Ab-1/ GM-Tg-bovg-T86072-Ab-2; GM-Tg-equg-T86072-Ab-1/ GM-Tg-equg-T86072-Ab-2 |
| Products Name | Anti-LRP5 monoclonal antibody |
| Format | mab |
| Target Name | LRP5 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-LRP5 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species LRP5/ BMND1/ EVR1 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-T86072 |
| Target Name | LRP5 |
| Gene ID | 4041,16973,293649,721605,100306933,101084481,534450,100147353 |
| Gene Symbol and Synonyms | BMND1,EVR1,EVR4,HBM,LR3,LRP-5,LRP-7,LRP5,LRP5L,LRP7,mKIAA4142,OPPG,OPS,OPTA1,PCLD4,VBCH2 |
| Uniprot Accession | O75197 |
| Uniprot Entry Name | LRP5_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000162337 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: LRP5, gene name: LRP5, also named as BMND1, EVR1, EVR4, HBM, LR3, LRP-5, LRP-7, LRP7, OPPG, OPS, OPTA1, PCLD4, VBCH2. This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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