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Anti-AURKA monoclonal antibody
Pre-made anti-AURKA monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to AURKA/AURKA products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T87675-Ab-1/ GM-Tg-hg-T87675-Ab-2 | Anti-Human AURKA monoclonal antibody | Human |
| GM-Tg-rg-T87675-Ab-1/ GM-Tg-rg-T87675-Ab-2 | Anti-Rat AURKA monoclonal antibody | Rat |
| GM-Tg-mg-T87675-Ab-1/ GM-Tg-mg-T87675-Ab-2 | Anti-Mouse AURKA monoclonal antibody | Mouse |
| GM-Tg-cynog-T87675-Ab-1/ GM-Tg-cynog-T87675-Ab-2 | Anti-Cynomolgus/ Rhesus macaque AURKA monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T87675-Ab-1/ GM-Tg-felg-T87675-Ab-2 | Anti-Feline AURKA monoclonal antibody | Feline |
| GM-Tg-cang-T87675-Ab-1/ GM-Tg-cang-T87675-Ab-2 | Anti-Canine AURKA monoclonal antibody | Canine |
| GM-Tg-bovg-T87675-Ab-1/ GM-Tg-bovg-T87675-Ab-2 | Anti-Bovine AURKA monoclonal antibody | Bovine |
| GM-Tg-equg-T87675-Ab-1/ GM-Tg-equg-T87675-Ab-2 | Anti-Equine AURKA monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T87675-Ab-1/ GM-Tg-hg-T87675-Ab-2; GM-Tg-rg-T87675-Ab-1/ GM-Tg-rg-T87675-Ab-2; GM-Tg-mg-T87675-Ab-1/ GM-Tg-mg-T87675-Ab-2; GM-Tg-cynog-T87675-Ab-1/ GM-Tg-cynog-T87675-Ab-2; GM-Tg-felg-T87675-Ab-1/ GM-Tg-felg-T87675-Ab-2; GM-Tg-cang-T87675-Ab-1/ GM-Tg-cang-T87675-Ab-2; GM-Tg-bovg-T87675-Ab-1/ GM-Tg-bovg-T87675-Ab-2; GM-Tg-equg-T87675-Ab-1/ GM-Tg-equg-T87675-Ab-2 |
| Products Name | Anti-AURKA monoclonal antibody |
| Format | mab |
| Target Name | AURKA |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-AURKA monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T87675-Ag-1 | Recombinant multi-species AURKA/ AIK/ ARK1 protein |
| ORF Viral Vector | pGMLPm002110 | mouse Aurka Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002110 | mouse Aurka Lentivirus particle |
Target information
| Target ID | GM-T87675 |
| Target Name | AURKA |
| Gene ID | 6790,20878,261730,698190,485940,101091184,504437,100050161 |
| Gene Symbol and Synonyms | AIK,AIRK1,ARK-1,ARK1,AURA,AURKA,Aurora-A,Ayk1,BTAK,IAK,IAK1,PPP1R47,STK15,STK6,STK7 |
| Uniprot Accession | O14965,P59241,Q2TA06 |
| Uniprot Entry Name | AURKA_HUMAN,AURKA_RAT,AURKA_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000087586 |
| Target Classification | Kinase, Tumor-associated antigen (TAA) |
The target: AURKA, gene name: AURKA, also named as AIK, ARK1, AURA, BTAK, PPP1R47, STK15, STK6, STK7. The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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