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Anti-CXB2/ Cx26/ GJB2 monoclonal antibody
Anti-CXB2/ Cx26/ GJB2 antibody for FACS & in-vivo assay
Go to Cx26/GJB2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T88947-Ab-1/ GM-Tg-hg-T88947-Ab-2 | Anti-Human Cx26/GJB2 monoclonal antibody | Human |
| GM-Tg-rg-T88947-Ab-1/ GM-Tg-rg-T88947-Ab-2 | Anti-Rat Cx26/GJB2 monoclonal antibody | Rat |
| GM-Tg-mg-T88947-Ab-1/ GM-Tg-mg-T88947-Ab-2 | Anti-Mouse Cx26/GJB2 monoclonal antibody | Mouse |
| GM-Tg-cynog-T88947-Ab-1/ GM-Tg-cynog-T88947-Ab-2 | Anti-Cynomolgus/ Rhesus macaque Cx26/GJB2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T88947-Ab-1/ GM-Tg-felg-T88947-Ab-2 | Anti-Feline Cx26/GJB2 monoclonal antibody | Feline |
| GM-Tg-cang-T88947-Ab-1/ GM-Tg-cang-T88947-Ab-2 | Anti-Canine Cx26/GJB2 monoclonal antibody | Canine |
| GM-Tg-bovg-T88947-Ab-1/ GM-Tg-bovg-T88947-Ab-2 | Anti-Bovine Cx26/GJB2 monoclonal antibody | Bovine |
| GM-Tg-equg-T88947-Ab-1/ GM-Tg-equg-T88947-Ab-2 | Anti-Equine Cx26/GJB2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T88947-Ab-1/ GM-Tg-hg-T88947-Ab-2; GM-Tg-rg-T88947-Ab-1/ GM-Tg-rg-T88947-Ab-2; GM-Tg-mg-T88947-Ab-1/ GM-Tg-mg-T88947-Ab-2; GM-Tg-cynog-T88947-Ab-1/ GM-Tg-cynog-T88947-Ab-2; GM-Tg-felg-T88947-Ab-1/ GM-Tg-felg-T88947-Ab-2; GM-Tg-cang-T88947-Ab-1/ GM-Tg-cang-T88947-Ab-2; GM-Tg-bovg-T88947-Ab-1/ GM-Tg-bovg-T88947-Ab-2; GM-Tg-equg-T88947-Ab-1/ GM-Tg-equg-T88947-Ab-2 |
| Products Name | Anti-Cx26/GJB2 monoclonal antibody |
| Format | mab |
| Target Name | Cx26 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-Cx26 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species CXB2/ Cx26/ GJB2 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMAP000519 | Human GJB2 Adenovirus particle |
| ORF Viral Vector | pGMAP000033 | Human GJB2 Adenovirus plasmid |
| ORF Viral Vector | pGMAP000519 | Human GJB2 Adenovirus plasmid |
| ORF Viral Vector | vGMAP000033 | Human GJB2 Adenovirus particle |
| ORF Viral Vector | pGMLPm002823 | mouse Gjb2 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002823 | mouse Gjb2 Lentivirus particle |
Target information
| Target ID | GM-T88947 |
| Target Name | Cx26 |
| Gene ID | 2706,14619,394266,704224,403570,101082540,407154,100050084 |
| Gene Symbol and Synonyms | BAPS,Cnx26,CX26,CXN-26,Cxne,DFNA3,DFNA3A,DFNB1,DFNB1A,Gjb-2,GJB2,HID,KID,NSRD1,PPK |
| Uniprot Accession | P29033,P21994,Q8MIT8,A2VE67 |
| Uniprot Entry Name | CXB2_HUMAN,CXB2_MACMU,CXB2_RAT,CXB2_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000165474 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: Cx26, gene name: GJB2, also named as CX26, DFNA3, DFNA3A, DFNB1, DFNB1A, HID, KID, NSRD1, PPK. This gene encodes a member of the gap junction protein family. The gap junctions were first characterized by electron microscopy as regionally specialized structures on plasma membranes of contacting adherent cells. These structures were shown to consist of cell-to-cell channels that facilitate the transfer of ions and small molecules between cells. The gap junction proteins, also known as connexins, purified from fractions of enriched gap junctions from different tissues differ. According to sequence similarities at the nucleotide and amino acid levels, the gap junction proteins are divided into two categories, alpha and beta. Mutations in this gene are responsible for as much as 50% of pre-lingual, recessive deafness. [provided by RefSeq, Oct 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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