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Anti-SOD Mn monoclonal antibody
Pre-made anti-SOD Mn monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to SOD Mn/SOD2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T89147-Ab-1/ GM-Tg-hg-T89147-Ab-2 | Anti-Human SOD Mn/SOD2 monoclonal antibody | Human |
| GM-Tg-rg-T89147-Ab-1/ GM-Tg-rg-T89147-Ab-2 | Anti-Rat SOD Mn/SOD2 monoclonal antibody | Rat |
| GM-Tg-mg-T89147-Ab-1/ GM-Tg-mg-T89147-Ab-2 | Anti-Mouse SOD Mn/SOD2 monoclonal antibody | Mouse |
| GM-Tg-cynog-T89147-Ab-1/ GM-Tg-cynog-T89147-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SOD Mn/SOD2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T89147-Ab-1/ GM-Tg-felg-T89147-Ab-2 | Anti-Feline SOD Mn/SOD2 monoclonal antibody | Feline |
| GM-Tg-cang-T89147-Ab-1/ GM-Tg-cang-T89147-Ab-2 | Anti-Canine SOD Mn/SOD2 monoclonal antibody | Canine |
| GM-Tg-bovg-T89147-Ab-1/ GM-Tg-bovg-T89147-Ab-2 | Anti-Bovine SOD Mn/SOD2 monoclonal antibody | Bovine |
| GM-Tg-equg-T89147-Ab-1/ GM-Tg-equg-T89147-Ab-2 | Anti-Equine SOD Mn/SOD2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T89147-Ab-1/ GM-Tg-hg-T89147-Ab-2; GM-Tg-rg-T89147-Ab-1/ GM-Tg-rg-T89147-Ab-2; GM-Tg-mg-T89147-Ab-1/ GM-Tg-mg-T89147-Ab-2; GM-Tg-cynog-T89147-Ab-1/ GM-Tg-cynog-T89147-Ab-2; GM-Tg-felg-T89147-Ab-1/ GM-Tg-felg-T89147-Ab-2; GM-Tg-cang-T89147-Ab-1/ GM-Tg-cang-T89147-Ab-2; GM-Tg-bovg-T89147-Ab-1/ GM-Tg-bovg-T89147-Ab-2; GM-Tg-equg-T89147-Ab-1/ GM-Tg-equg-T89147-Ab-2 |
| Products Name | Anti-SOD Mn/SOD2 monoclonal antibody |
| Format | mab |
| Target Name | SOD Mn |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-SOD Mn monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T89147-Ag-1 | Recombinant multi-species SODM/ SOD Mn/ SOD2 protein |
| ORF Viral Vector | vGMAAV000363 | human SOD2 AAV particle |
| ORF Viral Vector | pGMAP000391 | Human SOD2 Adenovirus plasmid |
| ORF Viral Vector | pGMAAV000363 | human SOD2 AAV plasmid |
| ORF Viral Vector | vGMAP000391 | Human SOD2 Adenovirus particle |
| ORF Viral Vector | pGMLPm000448 | mouse Sod2 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000448 | mouse Sod2 Lentivirus particle |
Target information
| Target ID | GM-T89147 |
| Target Name | SOD Mn |
| Gene ID | 6648,20656,24787,574097,476258,101096985,281496,100034223 |
| Gene Symbol and Synonyms | GC1,GClnc1,IPO-B,IPOB,Mn-SOD,MNSOD,MVCD6,Sod-2,SOD2,SOD2X1,SOD2X2 |
| Uniprot Accession | P04179,P07895,Q8HXP2,P54712,P41976,Q9XS41 |
| Uniprot Entry Name | SODM_HUMAN,SODM_MACMU,SODM_RAT,SODM_CANLF,SODM_BOVIN,SODM_HORSE |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000112096 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: SOD Mn, gene name: SOD2, also named as IPO-B, IPOB, MNSOD, MVCD6, Mn-SOD. This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. [provided by RefSeq, Apr 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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