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Anti-IGF2/ C11orf43/ GRDF functional antibody
Anti-IGF2/ C11orf43/ GRDF functional antibody for cell culture, ELISA & in-vivo assay
Go to IGF2/IGF2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T90572-Ab-1/ GM-Tg-hg-T90572-Ab-2 | Anti-Human IGF2 monoclonal antibody | Human |
| GM-Tg-rg-T90572-Ab-1/ GM-Tg-rg-T90572-Ab-2 | Anti-Rat IGF2 monoclonal antibody | Rat |
| GM-Tg-mg-T90572-Ab-1/ GM-Tg-mg-T90572-Ab-2 | Anti-Mouse IGF2 monoclonal antibody | Mouse |
| GM-Tg-cynog-T90572-Ab-1/ GM-Tg-cynog-T90572-Ab-2 | Anti-Cynomolgus/ Rhesus macaque IGF2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T90572-Ab-1/ GM-Tg-felg-T90572-Ab-2 | Anti-Feline IGF2 monoclonal antibody | Feline |
| GM-Tg-cang-T90572-Ab-1/ GM-Tg-cang-T90572-Ab-2 | Anti-Canine IGF2 monoclonal antibody | Canine |
| GM-Tg-bovg-T90572-Ab-1/ GM-Tg-bovg-T90572-Ab-2 | Anti-Bovine IGF2 monoclonal antibody | Bovine |
| GM-Tg-equg-T90572-Ab-1/ GM-Tg-equg-T90572-Ab-2 | Anti-Equine IGF2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T90572-Ab-1/ GM-Tg-hg-T90572-Ab-2; GM-Tg-rg-T90572-Ab-1/ GM-Tg-rg-T90572-Ab-2; GM-Tg-mg-T90572-Ab-1/ GM-Tg-mg-T90572-Ab-2; GM-Tg-cynog-T90572-Ab-1/ GM-Tg-cynog-T90572-Ab-2; GM-Tg-felg-T90572-Ab-1/ GM-Tg-felg-T90572-Ab-2; GM-Tg-cang-T90572-Ab-1/ GM-Tg-cang-T90572-Ab-2; GM-Tg-bovg-T90572-Ab-1/ GM-Tg-bovg-T90572-Ab-2; GM-Tg-equg-T90572-Ab-1/ GM-Tg-equg-T90572-Ab-2 |
| Products Name | Anti-IGF2 monoclonal antibody |
| Format | mab |
| Target Name | IGF2 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-IGF2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Target information
| Target ID | GM-T90572 |
| Target Name | IGF2 |
| Gene ID | 3481,16002,24483,710802,483664,101093644,281240,100034182 |
| Gene Symbol and Synonyms | C11orf43,GRDF,Igf-2,IGF-II,IGF2,IGFII,M6pr,Mpr,Peg2,PP9974,RNIGF2,SRS3 |
| Uniprot Accession | P01344,P01346,P07456,P51459 |
| Uniprot Entry Name | IGF2_HUMAN,IGF2_RAT,IGF2_BOVIN,IGF2_HORSE |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, INN Index, Cytokine Target |
| Disease | Ovary Cancer |
| Gene Ensembl | ENSG00000167244 |
| Target Classification | N/A |
The target: IGF2, gene name: IGF2, also named as C11orf43, GRDF, IGF-II, PP9974. This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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