Anti-LGR4/ BNMD17/ GPR48 monoclonal antibody

Anti-LGR4/ BNMD17/ GPR48 antibody for FACS & in-vivo assay

Target products collectionGo to LGR4/LGR4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T90672-Ab-1/ GM-Tg-hg-T90672-Ab-2Anti-Human LGR4 monoclonal antibodyHuman
GM-Tg-rg-T90672-Ab-1/ GM-Tg-rg-T90672-Ab-2Anti-Rat LGR4 monoclonal antibodyRat
GM-Tg-mg-T90672-Ab-1/ GM-Tg-mg-T90672-Ab-2Anti-Mouse LGR4 monoclonal antibodyMouse
GM-Tg-cynog-T90672-Ab-1/ GM-Tg-cynog-T90672-Ab-2Anti-Cynomolgus/ Rhesus macaque LGR4 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T90672-Ab-1/ GM-Tg-felg-T90672-Ab-2Anti-Feline LGR4 monoclonal antibodyFeline
GM-Tg-cang-T90672-Ab-1/ GM-Tg-cang-T90672-Ab-2Anti-Canine LGR4 monoclonal antibodyCanine
GM-Tg-bovg-T90672-Ab-1/ GM-Tg-bovg-T90672-Ab-2Anti-Bovine LGR4 monoclonal antibodyBovine
GM-Tg-equg-T90672-Ab-1/ GM-Tg-equg-T90672-Ab-2Anti-Equine LGR4 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T90672-Ab-1/ GM-Tg-hg-T90672-Ab-2; GM-Tg-rg-T90672-Ab-1/ GM-Tg-rg-T90672-Ab-2;
GM-Tg-mg-T90672-Ab-1/ GM-Tg-mg-T90672-Ab-2; GM-Tg-cynog-T90672-Ab-1/ GM-Tg-cynog-T90672-Ab-2;
GM-Tg-felg-T90672-Ab-1/ GM-Tg-felg-T90672-Ab-2; GM-Tg-cang-T90672-Ab-1/ GM-Tg-cang-T90672-Ab-2;
GM-Tg-bovg-T90672-Ab-1/ GM-Tg-bovg-T90672-Ab-2; GM-Tg-equg-T90672-Ab-1/ GM-Tg-equg-T90672-Ab-2
Products NameAnti-LGR4 monoclonal antibody
Formatmab
Target NameLGR4
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-LGR4 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species LGR4/ BNMD17/ GPR48 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMLV000018mouse Lgr4 Lentivirus plasmid
    ORF Viral VectorvGMLV000018mouse Lgr4 Lentivirus particle


    Target information

    Target IDGM-T90672
    Target NameLGR4
    Gene ID55366,107515,286994,701736,476896,101083964,505423,100072305
    Gene Symbol and Synonyms9130225G07,A330106J01Rik,A930009A08Rik,BNMD17,DPSL,GPR48,LGR4
    Uniprot AccessionQ9BXB1,Q9Z2H4,F1MLX5
    Uniprot Entry NameLGR4_HUMAN,LGR4_RAT,LGR4_BOVIN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseN/A
    Gene EnsemblENSG00000205213
    Target ClassificationGPCR

    The target: LGR4, gene name: LGR4, also named as BNMD17, GPR48. The protein encoded by this gene is a G-protein coupled receptor that binds R-spondins and activates the Wnt signaling pathway. This Wnt signaling pathway activation is necessary for proper development of many organs of the body. [provided by RefSeq, Oct 2016].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.