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Anti-FGFR4/ CD334/ JTK2 monoclonal antibody
Anti-FGFR4/ CD334/ JTK2 antibody for FACS & in-vivo assay
Go to FGFR4/FGFR4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T90989-Ab-1/ GM-Tg-hg-T90989-Ab-2 | Anti-Human FGFR4 monoclonal antibody | Human |
| GM-Tg-rg-T90989-Ab-1/ GM-Tg-rg-T90989-Ab-2 | Anti-Rat FGFR4 monoclonal antibody | Rat |
| GM-Tg-mg-T90989-Ab-1/ GM-Tg-mg-T90989-Ab-2 | Anti-Mouse FGFR4 monoclonal antibody | Mouse |
| GM-Tg-cynog-T90989-Ab-1/ GM-Tg-cynog-T90989-Ab-2 | Anti-Cynomolgus/ Rhesus macaque FGFR4 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T90989-Ab-1/ GM-Tg-felg-T90989-Ab-2 | Anti-Feline FGFR4 monoclonal antibody | Feline |
| GM-Tg-cang-T90989-Ab-1/ GM-Tg-cang-T90989-Ab-2 | Anti-Canine FGFR4 monoclonal antibody | Canine |
| GM-Tg-bovg-T90989-Ab-1/ GM-Tg-bovg-T90989-Ab-2 | Anti-Bovine FGFR4 monoclonal antibody | Bovine |
| GM-Tg-equg-T90989-Ab-1/ GM-Tg-equg-T90989-Ab-2 | Anti-Equine FGFR4 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T90989-Ab-1/ GM-Tg-hg-T90989-Ab-2; GM-Tg-rg-T90989-Ab-1/ GM-Tg-rg-T90989-Ab-2; GM-Tg-mg-T90989-Ab-1/ GM-Tg-mg-T90989-Ab-2; GM-Tg-cynog-T90989-Ab-1/ GM-Tg-cynog-T90989-Ab-2; GM-Tg-felg-T90989-Ab-1/ GM-Tg-felg-T90989-Ab-2; GM-Tg-cang-T90989-Ab-1/ GM-Tg-cang-T90989-Ab-2; GM-Tg-bovg-T90989-Ab-1/ GM-Tg-bovg-T90989-Ab-2; GM-Tg-equg-T90989-Ab-1/ GM-Tg-equg-T90989-Ab-2 |
| Products Name | Anti-FGFR4 monoclonal antibody |
| Format | mab |
| Target Name | FGFR4 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-FGFR4 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Biosimilar | GMP-Bios-INN-727 | Pre-Made Aldafermin Biosimilar, Recombinant Protein targeting FGFR4: Recombinant therapeutic protein targeting CD334/JTK2/TKF |
| Target Antigen | Products Developing | Multi-species FGFR4/ CD334/ JTK2 VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-T90989-Ag-1 | Fibroblast growth factor receptor 4 (FGFR4) protein |
| ORF Viral Vector | vGMLV000558 | human FGFR4 Lentivirus particle |
| ORF Viral Vector | pGMLV000558 | human FGFR4 Lentivirus plasmid |
Target information
| Target ID | GM-T90989 |
| Target Name | FGFR4 |
| Gene ID | 2264,14186,25114,698494,489095,101100864,317696,100068679 |
| Gene Symbol and Synonyms | CD334,Fgfr-4,FGFR4,JTK2,TKF |
| Uniprot Accession | P22455,Q498D6 |
| Uniprot Entry Name | FGFR4_HUMAN,FGFR4_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, INN Index, Cytokine Target |
| Disease | Breast Cancer, Ovary Cancer |
| Gene Ensembl | ENSG00000160867 |
| Target Classification | Kinase |
The target: FGFR4, gene name: FGFR4, also named as CD334, JTK2, TKF. The protein encoded by this gene is a tyrosine kinase and cell surface receptor for fibroblast growth factors. The encoded protein is involved in the regulation of several pathways, including cell proliferation, cell differentiation, cell migration, lipid metabolism, bile acid biosynthesis, vitamin D metabolism, glucose uptake, and phosphate homeostasis. This protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment, and a cytoplasmic tyrosine kinase domain. The extracellular portion interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. [provided by RefSeq, Aug 2017].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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