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Anti-TNR4/ CD134/ TNFRSF4 monoclonal antibody
Anti-TNR4/ CD134/ TNFRSF4 antibody for FACS & in-vivo assay
Go to CD134/TNFRSF4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T92124-Ab-1/ GM-Tg-hg-T92124-Ab-2 | Anti-Human CD134/TNFRSF4 monoclonal antibody | Human |
| GM-Tg-rg-T92124-Ab-1/ GM-Tg-rg-T92124-Ab-2 | Anti-Rat CD134/TNFRSF4 monoclonal antibody | Rat |
| GM-Tg-mg-T92124-Ab-1/ GM-Tg-mg-T92124-Ab-2 | Anti-Mouse CD134/TNFRSF4 monoclonal antibody | Mouse |
| GM-Tg-cynog-T92124-Ab-1/ GM-Tg-cynog-T92124-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CD134/TNFRSF4 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T92124-Ab-1/ GM-Tg-felg-T92124-Ab-2 | Anti-Feline CD134/TNFRSF4 monoclonal antibody | Feline |
| GM-Tg-cang-T92124-Ab-1/ GM-Tg-cang-T92124-Ab-2 | Anti-Canine CD134/TNFRSF4 monoclonal antibody | Canine |
| GM-Tg-bovg-T92124-Ab-1/ GM-Tg-bovg-T92124-Ab-2 | Anti-Bovine CD134/TNFRSF4 monoclonal antibody | Bovine |
| GM-Tg-equg-T92124-Ab-1/ GM-Tg-equg-T92124-Ab-2 | Anti-Equine CD134/TNFRSF4 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T92124-Ab-1/ GM-Tg-hg-T92124-Ab-2; GM-Tg-rg-T92124-Ab-1/ GM-Tg-rg-T92124-Ab-2; GM-Tg-mg-T92124-Ab-1/ GM-Tg-mg-T92124-Ab-2; GM-Tg-cynog-T92124-Ab-1/ GM-Tg-cynog-T92124-Ab-2; GM-Tg-felg-T92124-Ab-1/ GM-Tg-felg-T92124-Ab-2; GM-Tg-cang-T92124-Ab-1/ GM-Tg-cang-T92124-Ab-2; GM-Tg-bovg-T92124-Ab-1/ GM-Tg-bovg-T92124-Ab-2; GM-Tg-equg-T92124-Ab-1/ GM-Tg-equg-T92124-Ab-2 |
| Products Name | Anti-CD134/TNFRSF4 monoclonal antibody |
| Format | mab |
| Target Name | CD134 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CD134 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Target information
| Target ID | GM-T92124 |
| Target Name | CD134 |
| Gene ID | 7293,22163,25572,699674,489600,493665,528782,100066167 |
| Gene Symbol and Synonyms | ACT35,CD134,IMD16,Ly-70,OX40,TNFRSF4,Txgp1,TXGP1L |
| Uniprot Accession | P43489,P15725 |
| Uniprot Entry Name | TNR4_HUMAN,TNR4_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Immuno-oncology Target, INN Index, Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000186827 |
| Target Classification | Checkpoint-Immuno Oncology, GPCR |
The target: CD134, gene name: TNFRSF4, also named as ACT35, CD134, IMD16, OX40, TXGP1L. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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