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Anti-eEF-2K monoclonal antibody
Pre-made anti-eEF-2K monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to eEF-2K/EEF2K products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T92494-Ab-1/ GM-Tg-hg-T92494-Ab-2 | Anti-Human eEF-2K/EEF2K monoclonal antibody | Human |
| GM-Tg-rg-T92494-Ab-1/ GM-Tg-rg-T92494-Ab-2 | Anti-Rat eEF-2K/EEF2K monoclonal antibody | Rat |
| GM-Tg-mg-T92494-Ab-1/ GM-Tg-mg-T92494-Ab-2 | Anti-Mouse eEF-2K/EEF2K monoclonal antibody | Mouse |
| GM-Tg-cynog-T92494-Ab-1/ GM-Tg-cynog-T92494-Ab-2 | Anti-Cynomolgus/ Rhesus macaque eEF-2K/EEF2K monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T92494-Ab-1/ GM-Tg-felg-T92494-Ab-2 | Anti-Feline eEF-2K/EEF2K monoclonal antibody | Feline |
| GM-Tg-cang-T92494-Ab-1/ GM-Tg-cang-T92494-Ab-2 | Anti-Canine eEF-2K/EEF2K monoclonal antibody | Canine |
| GM-Tg-bovg-T92494-Ab-1/ GM-Tg-bovg-T92494-Ab-2 | Anti-Bovine eEF-2K/EEF2K monoclonal antibody | Bovine |
| GM-Tg-equg-T92494-Ab-1/ GM-Tg-equg-T92494-Ab-2 | Anti-Equine eEF-2K/EEF2K monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T92494-Ab-1/ GM-Tg-hg-T92494-Ab-2; GM-Tg-rg-T92494-Ab-1/ GM-Tg-rg-T92494-Ab-2; GM-Tg-mg-T92494-Ab-1/ GM-Tg-mg-T92494-Ab-2; GM-Tg-cynog-T92494-Ab-1/ GM-Tg-cynog-T92494-Ab-2; GM-Tg-felg-T92494-Ab-1/ GM-Tg-felg-T92494-Ab-2; GM-Tg-cang-T92494-Ab-1/ GM-Tg-cang-T92494-Ab-2; GM-Tg-bovg-T92494-Ab-1/ GM-Tg-bovg-T92494-Ab-2; GM-Tg-equg-T92494-Ab-1/ GM-Tg-equg-T92494-Ab-2 |
| Products Name | Anti-eEF-2K/EEF2K monoclonal antibody |
| Format | mab |
| Target Name | eEF-2K |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-eEF-2K monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T92494-Ag-1 | Recombinant multi-species EF2K/ eEF-2K/ EEF2K protein |
| ORF Viral Vector | vGMAP000137 | Human EEF2K Adenovirus particle |
| ORF Viral Vector | pGMAP000137 | Human EEF2K Adenovirus plasmid |
Target information
| Target ID | GM-T92494 |
| Target Name | eEF-2K |
| Gene ID | 29904,13631,25435,698604,479812,101101433,521730,100058387 |
| Gene Symbol and Synonyms | CaMKIII,eEF-2K,EEF2K,HSU93850,SMEF2K |
| Uniprot Accession | O00418,P70531 |
| Uniprot Entry Name | EF2K_HUMAN,EF2K_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000103319 |
| Target Classification | Kinase |
The target: eEF-2K, gene name: EEF2K, also named as CaMKIII, HSU93850, eEF-2K. This gene encodes a highly conserved protein kinase in the calmodulin-mediated signaling pathway that links activation of cell surface receptors to cell division. This kinase is involved in the regulation of protein synthesis. It phosphorylates eukaryotic elongation factor 2 (EEF2) and thus inhibits the EEF2 function. The activity of this kinase is increased in many cancers and may be a valid target for anti-cancer treatment. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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