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Anti-MALT1 monoclonal antibody
Pre-made anti-MALT1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to MALT1/MALT1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T92678-Ab-1/ GM-Tg-hg-T92678-Ab-2 | Anti-Human MALT1 monoclonal antibody | Human |
| GM-Tg-rg-T92678-Ab-1/ GM-Tg-rg-T92678-Ab-2 | Anti-Rat MALT1 monoclonal antibody | Rat |
| GM-Tg-mg-T92678-Ab-1/ GM-Tg-mg-T92678-Ab-2 | Anti-Mouse MALT1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T92678-Ab-1/ GM-Tg-cynog-T92678-Ab-2 | Anti-Cynomolgus/ Rhesus macaque MALT1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T92678-Ab-1/ GM-Tg-felg-T92678-Ab-2 | Anti-Feline MALT1 monoclonal antibody | Feline |
| GM-Tg-cang-T92678-Ab-1/ GM-Tg-cang-T92678-Ab-2 | Anti-Canine MALT1 monoclonal antibody | Canine |
| GM-Tg-bovg-T92678-Ab-1/ GM-Tg-bovg-T92678-Ab-2 | Anti-Bovine MALT1 monoclonal antibody | Bovine |
| GM-Tg-equg-T92678-Ab-1/ GM-Tg-equg-T92678-Ab-2 | Anti-Equine MALT1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T92678-Ab-1/ GM-Tg-hg-T92678-Ab-2; GM-Tg-rg-T92678-Ab-1/ GM-Tg-rg-T92678-Ab-2; GM-Tg-mg-T92678-Ab-1/ GM-Tg-mg-T92678-Ab-2; GM-Tg-cynog-T92678-Ab-1/ GM-Tg-cynog-T92678-Ab-2; GM-Tg-felg-T92678-Ab-1/ GM-Tg-felg-T92678-Ab-2; GM-Tg-cang-T92678-Ab-1/ GM-Tg-cang-T92678-Ab-2; GM-Tg-bovg-T92678-Ab-1/ GM-Tg-bovg-T92678-Ab-2; GM-Tg-equg-T92678-Ab-1/ GM-Tg-equg-T92678-Ab-2 |
| Products Name | Anti-MALT1 monoclonal antibody |
| Format | mab |
| Target Name | MALT1 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-MALT1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T92678-Ag-1 | Recombinant multi-species MALT1/ IMD12/ MLT protein |
Target information
| Target ID | GM-T92678 |
| Target Name | MALT1 |
| Gene ID | 10892,240354,307366,696354,476188,101088885,504994,100054579 |
| Gene Symbol and Synonyms | A630046N12,D430033E09Rik,IMD12,MALT1,MLT,MLT1,PCASP1 |
| Uniprot Accession | Q9UDY8 |
| Uniprot Entry Name | MALT1_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000172175 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: MALT1, gene name: MALT1, also named as IMD12, MLT, MLT1, PCASP1. This gene encodes a caspase-like protease that plays a role in BCL10-induced activation of NF-kappaB. The protein is a component of the CARMA1-BCL10-MALT1 (CBM) signalosome that triggers NF-kappaB signaling and lymphoctye activation following antigen-receptor stimulation. Mutations in this gene result in immunodeficiency 12 (IMD12). This gene has been found to be recurrently rearranged in chromosomal translocations with other genes in mucosa-associated lymphoid tissue lymphomas, including a t(11;18)(q21;q21) translocation with the baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) locus [BIRC3(API2)-MALT1], and a t(14;18)(q32;q21) translocation with the immunoglobulin heavy chain locus (IGH-MALT1). Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2018].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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