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Anti-CCL21/ 6Ckine/ CKb9 functional antibody
Anti-CCL21/ 6Ckine/ CKb9 functional antibody for cell culture, ELISA & in-vivo assay
Go to CCL21/CCL21 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T93237-Ab-1/ GM-Tg-hg-T93237-Ab-2 | Anti-Human CCL21 monoclonal antibody | Human |
| GM-Tg-rg-T93237-Ab-1/ GM-Tg-rg-T93237-Ab-2 | Anti-Rat CCL21 monoclonal antibody | Rat |
| GM-Tg-mg-T93237-Ab-1/ GM-Tg-mg-T93237-Ab-2 | Anti-Mouse CCL21 monoclonal antibody | Mouse |
| GM-Tg-cynog-T93237-Ab-1/ GM-Tg-cynog-T93237-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CCL21 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T93237-Ab-1/ GM-Tg-felg-T93237-Ab-2 | Anti-Feline CCL21 monoclonal antibody | Feline |
| GM-Tg-cang-T93237-Ab-1/ GM-Tg-cang-T93237-Ab-2 | Anti-Canine CCL21 monoclonal antibody | Canine |
| GM-Tg-bovg-T93237-Ab-1/ GM-Tg-bovg-T93237-Ab-2 | Anti-Bovine CCL21 monoclonal antibody | Bovine |
| GM-Tg-equg-T93237-Ab-1/ GM-Tg-equg-T93237-Ab-2 | Anti-Equine CCL21 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T93237-Ab-1/ GM-Tg-hg-T93237-Ab-2; GM-Tg-rg-T93237-Ab-1/ GM-Tg-rg-T93237-Ab-2; GM-Tg-mg-T93237-Ab-1/ GM-Tg-mg-T93237-Ab-2; GM-Tg-cynog-T93237-Ab-1/ GM-Tg-cynog-T93237-Ab-2; GM-Tg-felg-T93237-Ab-1/ GM-Tg-felg-T93237-Ab-2; GM-Tg-cang-T93237-Ab-1/ GM-Tg-cang-T93237-Ab-2; GM-Tg-bovg-T93237-Ab-1/ GM-Tg-bovg-T93237-Ab-2; GM-Tg-equg-T93237-Ab-1/ GM-Tg-equg-T93237-Ab-2 |
| Products Name | Anti-CCL21 monoclonal antibody |
| Format | mab |
| Target Name | CCL21 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CCL21 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T93237-Ag-1 | Recombinant multi-species CCL21/ 6Ckine/ CKb9 protein |
| Cytokine | GM-Tg-g-T93237-Ag-1 | chemokine (C-C motif) ligand 21 (CCL21) protein |
| ORF Viral Vector | vGMLP002050 | human CCL21 Lentivirus particle |
| ORF Viral Vector | pGMLP002050 | human CCL21 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm003403 | mouse Ccl21c Lentivirus plasmid |
| ORF Viral Vector | pGMLPm003512 | mouse Ccl21a Lentivirus plasmid |
| ORF Viral Vector | vGMLPm003403 | mouse Ccl21c Lentivirus particle |
| ORF Viral Vector | vGMLPm003512 | mouse Ccl21a Lentivirus particle |
Target information
| Target ID | GM-T93237 |
| Target Name | CCL21 |
| Gene ID | 6366,18829,298006,574183,448796,101087275,511112 |
| Gene Symbol and Synonyms | 6CKBAC2,6Ckine,ALP,CCL21,Ccl21a,Ccl21b,CKb9,ECL,Gm1987,plt,SCYA21,SCYA21a,Scya21b,SLC,TCA4 |
| Uniprot Accession | O00585,Q8HYP5 |
| Uniprot Entry Name | CCL21_HUMAN,CCL21_MACMU |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, Cytokine Target |
| Disease | ovarian cancer |
| Gene Ensembl | ENSG00000137077 |
| Target Classification | N/A |
The target: CCL21, gene name: CCL21, also named as 6Ckine, CKb9, ECL, SCYA21, SLC, TCA4. This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19). [provided by RefSeq, Sep 2014].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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