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Anti-S12A1/ SLC12A1/ BSC1 monoclonal antibody
Anti-S12A1/ SLC12A1/ BSC1 antibody for FACS & in-vivo assay
Go to SLC12A1/SLC12A1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T93878-Ab-1/ GM-Tg-hg-T93878-Ab-2 | Anti-Human SLC12A1 monoclonal antibody | Human |
| GM-Tg-rg-T93878-Ab-1/ GM-Tg-rg-T93878-Ab-2 | Anti-Rat SLC12A1 monoclonal antibody | Rat |
| GM-Tg-mg-T93878-Ab-1/ GM-Tg-mg-T93878-Ab-2 | Anti-Mouse SLC12A1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T93878-Ab-1/ GM-Tg-cynog-T93878-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SLC12A1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T93878-Ab-1/ GM-Tg-felg-T93878-Ab-2 | Anti-Feline SLC12A1 monoclonal antibody | Feline |
| GM-Tg-cang-T93878-Ab-1/ GM-Tg-cang-T93878-Ab-2 | Anti-Canine SLC12A1 monoclonal antibody | Canine |
| GM-Tg-bovg-T93878-Ab-1/ GM-Tg-bovg-T93878-Ab-2 | Anti-Bovine SLC12A1 monoclonal antibody | Bovine |
| GM-Tg-equg-T93878-Ab-1/ GM-Tg-equg-T93878-Ab-2 | Anti-Equine SLC12A1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T93878-Ab-1/ GM-Tg-hg-T93878-Ab-2; GM-Tg-rg-T93878-Ab-1/ GM-Tg-rg-T93878-Ab-2; GM-Tg-mg-T93878-Ab-1/ GM-Tg-mg-T93878-Ab-2; GM-Tg-cynog-T93878-Ab-1/ GM-Tg-cynog-T93878-Ab-2; GM-Tg-felg-T93878-Ab-1/ GM-Tg-felg-T93878-Ab-2; GM-Tg-cang-T93878-Ab-1/ GM-Tg-cang-T93878-Ab-2; GM-Tg-bovg-T93878-Ab-1/ GM-Tg-bovg-T93878-Ab-2; GM-Tg-equg-T93878-Ab-1/ GM-Tg-equg-T93878-Ab-2 |
| Products Name | Anti-SLC12A1 monoclonal antibody |
| Format | mab |
| Target Name | SLC12A1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-SLC12A1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species S12A1/ SLC12A1/ BSC1 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-T93878 |
| Target Name | SLC12A1 |
| Gene ID | 6557,20495,25065,714289,478292,101100216,407161 |
| Gene Symbol and Synonyms | BSC,BSC-1,BSC1,CCC2,D630042G03Rik,mBSC1,NKCC2,SLC12A1,urehr3 |
| Uniprot Accession | Q13621,P55016 |
| Uniprot Entry Name | S12A1_HUMAN,S12A1_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | Hyperaldosteronism |
| Gene Ensembl | ENSG00000074803 |
| Target Classification | N/A |
The target: SLC12A1, gene name: SLC12A1, also named as BSC1, NKCC2. This gene encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity in humans has not been experimentally proven.[provided by RefSeq, May 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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