Anti-YAP1 monoclonal antibody

Pre-made anti-YAP1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to YAP1/YAP1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T94048-Ab-1/ GM-Tg-hg-T94048-Ab-2Anti-Human YAP1 monoclonal antibodyHuman
GM-Tg-rg-T94048-Ab-1/ GM-Tg-rg-T94048-Ab-2Anti-Rat YAP1 monoclonal antibodyRat
GM-Tg-mg-T94048-Ab-1/ GM-Tg-mg-T94048-Ab-2Anti-Mouse YAP1 monoclonal antibodyMouse
GM-Tg-cynog-T94048-Ab-1/ GM-Tg-cynog-T94048-Ab-2Anti-Cynomolgus/ Rhesus macaque YAP1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T94048-Ab-1/ GM-Tg-felg-T94048-Ab-2Anti-Feline YAP1 monoclonal antibodyFeline
GM-Tg-cang-T94048-Ab-1/ GM-Tg-cang-T94048-Ab-2Anti-Canine YAP1 monoclonal antibodyCanine
GM-Tg-bovg-T94048-Ab-1/ GM-Tg-bovg-T94048-Ab-2Anti-Bovine YAP1 monoclonal antibodyBovine
GM-Tg-equg-T94048-Ab-1/ GM-Tg-equg-T94048-Ab-2Anti-Equine YAP1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T94048-Ab-1/ GM-Tg-hg-T94048-Ab-2; GM-Tg-rg-T94048-Ab-1/ GM-Tg-rg-T94048-Ab-2;
GM-Tg-mg-T94048-Ab-1/ GM-Tg-mg-T94048-Ab-2; GM-Tg-cynog-T94048-Ab-1/ GM-Tg-cynog-T94048-Ab-2;
GM-Tg-felg-T94048-Ab-1/ GM-Tg-felg-T94048-Ab-2; GM-Tg-cang-T94048-Ab-1/ GM-Tg-cang-T94048-Ab-2;
GM-Tg-bovg-T94048-Ab-1/ GM-Tg-bovg-T94048-Ab-2; GM-Tg-equg-T94048-Ab-1/ GM-Tg-equg-T94048-Ab-2
Products NameAnti-YAP1 monoclonal antibody
Formatmab
Target NameYAP1
Protein Sub-locationIntrocelluar Protein
Category of antibodyTherapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-YAP1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-T94048-Ag-1Recombinant multi-species YAP1/ COB1/ YAP protein
    ORF Viral VectorvGMAAV000314human YAP1 AAV particle
    ORF Viral VectorvGMAD000620human YAP1 Adenovirus particle
    ORF Viral VectorpGMLV000567human YAP1 Lentivirus plasmid
    ORF Viral VectorvGMLV000567human YAP1 Lentivirus particle
    ORF Viral VectorvGMAD000063human YAP1 Adenovirus particle
    ORF Viral VectorpGMLV000392human YAP1 Lentivirus plasmid
    ORF Viral VectorvGMLV000392human YAP1 Lentivirus particle
    ORF Viral VectorpGMAD000063human YAP1 Adenovirus plasmid
    ORF Viral VectorpGMAAV000314human YAP1 AAV plasmid
    ORF Viral VectorpGMLV000777human YAP1 Lentivirus plasmid
    ORF Viral VectorpGMAD000620human YAP1 Adenovirus plasmid
    ORF Viral VectorvGMLV000777human YAP1 Lentivirus particle
    ORF Viral VectorpGMAD000081mouse Yap1 Adenovirus plasmid
    ORF Viral VectorpGMAD000508house mouse Yap1 Adenovirus plasmid
    ORF Viral VectorpGMAAV000106mouse Yap1 AAV plasmid
    ORF Viral VectorvGMAD000081mouse Yap1 Adenovirus particle
    ORF Viral VectorvGMAD000508house mouse Yap1 Adenovirus particle
    ORF Viral VectorvGMAAV000106mouse Yap1 AAV particle


    Target information

    Target IDGM-T94048
    Target NameYAP1
    Gene ID10413,22601,363014,704382,479465,101101408,100336629,100068834
    Gene Symbol and SynonymsCOB1,YAP,YAP-1,YAP-65,YAP1,YAP2,YAP65,YKI,Yorkie
    Uniprot AccessionP46937,Q2EJA0
    Uniprot Entry NameYAP1_HUMAN,YAP1_RAT
    Protein Sub-locationIntrocelluar Protein
    CategoryTherapeutics Target
    DiseaseCancer
    Gene EnsemblENSG00000137693
    Target ClassificationTumor-associated antigen (TAA)

    The target: YAP1, gene name: YAP1, also named as COB1, YAP, YAP2, YAP65, YKI. This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2013].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.