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Anti-RARA/ NR1B1/ RAR monoclonal antibody
Anti-RARA/ NR1B1/ RAR antibody for FACS & in-vivo assay
Go to RARA/RARA products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T94085-Ab-1/ GM-Tg-hg-T94085-Ab-2 | Anti-Human RARA monoclonal antibody | Human |
| GM-Tg-rg-T94085-Ab-1/ GM-Tg-rg-T94085-Ab-2 | Anti-Rat RARA monoclonal antibody | Rat |
| GM-Tg-mg-T94085-Ab-1/ GM-Tg-mg-T94085-Ab-2 | Anti-Mouse RARA monoclonal antibody | Mouse |
| GM-Tg-cynog-T94085-Ab-1/ GM-Tg-cynog-T94085-Ab-2 | Anti-Cynomolgus/ Rhesus macaque RARA monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T94085-Ab-1/ GM-Tg-felg-T94085-Ab-2 | Anti-Feline RARA monoclonal antibody | Feline |
| GM-Tg-cang-T94085-Ab-1/ GM-Tg-cang-T94085-Ab-2 | Anti-Canine RARA monoclonal antibody | Canine |
| GM-Tg-bovg-T94085-Ab-1/ GM-Tg-bovg-T94085-Ab-2 | Anti-Bovine RARA monoclonal antibody | Bovine |
| GM-Tg-equg-T94085-Ab-1/ GM-Tg-equg-T94085-Ab-2 | Anti-Equine RARA monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T94085-Ab-1/ GM-Tg-hg-T94085-Ab-2; GM-Tg-rg-T94085-Ab-1/ GM-Tg-rg-T94085-Ab-2; GM-Tg-mg-T94085-Ab-1/ GM-Tg-mg-T94085-Ab-2; GM-Tg-cynog-T94085-Ab-1/ GM-Tg-cynog-T94085-Ab-2; GM-Tg-felg-T94085-Ab-1/ GM-Tg-felg-T94085-Ab-2; GM-Tg-cang-T94085-Ab-1/ GM-Tg-cang-T94085-Ab-2; GM-Tg-bovg-T94085-Ab-1/ GM-Tg-bovg-T94085-Ab-2; GM-Tg-equg-T94085-Ab-1/ GM-Tg-equg-T94085-Ab-2 |
| Products Name | Anti-RARA monoclonal antibody |
| Format | mab |
| Target Name | RARA |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-RARA benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species RARA/ NR1B1/ RAR VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP000651 | human RARA Lentivirus particle |
| ORF Viral Vector | pGMAP000217 | Human RARA Adenovirus plasmid |
| ORF Viral Vector | pGMLP000651 | human RARA Lentivirus plasmid |
| ORF Viral Vector | vGMLP001994 | human RARA Lentivirus particle |
| ORF Viral Vector | pGMLP001994 | human RARA Lentivirus plasmid |
| ORF Viral Vector | vGMAP000217 | Human RARA Adenovirus particle |
| ORF Viral Vector | pGMLPm005223 | mouse Rara Lentivirus plasmid |
| ORF Viral Vector | vGMLPm005223 | mouse Rara Lentivirus particle |
Target information
| Target ID | GM-T94085 |
| Target Name | RARA |
| Gene ID | 5914,19401,24705,700206,480526,101083048,534280,100054274 |
| Gene Symbol and Synonyms | HS-RARa,NR1B1,RAR,RARA,RARalpha,RARalpha1 |
| Uniprot Accession | P10276,Q5FBR4 |
| Uniprot Entry Name | RARA_HUMAN,RARA_CANLF |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000131759 |
| Target Classification | Nuclear Receptors, Tumor-associated antigen (TAA) |
The target: RARA, gene name: RARA, also named as NR1B1, RAR. This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.[provided by RefSeq, Sep 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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