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Anti-MERL/ NF2/ ACN monoclonal antibody
Anti-MERL/ NF2/ ACN antibody for FACS & in-vivo assay
Go to NF2/NF2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T95742-Ab-1/ GM-Tg-hg-T95742-Ab-2 | Anti-Human NF2 monoclonal antibody | Human |
| GM-Tg-rg-T95742-Ab-1/ GM-Tg-rg-T95742-Ab-2 | Anti-Rat NF2 monoclonal antibody | Rat |
| GM-Tg-mg-T95742-Ab-1/ GM-Tg-mg-T95742-Ab-2 | Anti-Mouse NF2 monoclonal antibody | Mouse |
| GM-Tg-cynog-T95742-Ab-1/ GM-Tg-cynog-T95742-Ab-2 | Anti-Cynomolgus/ Rhesus macaque NF2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T95742-Ab-1/ GM-Tg-felg-T95742-Ab-2 | Anti-Feline NF2 monoclonal antibody | Feline |
| GM-Tg-cang-T95742-Ab-1/ GM-Tg-cang-T95742-Ab-2 | Anti-Canine NF2 monoclonal antibody | Canine |
| GM-Tg-bovg-T95742-Ab-1/ GM-Tg-bovg-T95742-Ab-2 | Anti-Bovine NF2 monoclonal antibody | Bovine |
| GM-Tg-equg-T95742-Ab-1/ GM-Tg-equg-T95742-Ab-2 | Anti-Equine NF2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T95742-Ab-1/ GM-Tg-hg-T95742-Ab-2; GM-Tg-rg-T95742-Ab-1/ GM-Tg-rg-T95742-Ab-2; GM-Tg-mg-T95742-Ab-1/ GM-Tg-mg-T95742-Ab-2; GM-Tg-cynog-T95742-Ab-1/ GM-Tg-cynog-T95742-Ab-2; GM-Tg-felg-T95742-Ab-1/ GM-Tg-felg-T95742-Ab-2; GM-Tg-cang-T95742-Ab-1/ GM-Tg-cang-T95742-Ab-2; GM-Tg-bovg-T95742-Ab-1/ GM-Tg-bovg-T95742-Ab-2; GM-Tg-equg-T95742-Ab-1/ GM-Tg-equg-T95742-Ab-2 |
| Products Name | Anti-NF2 monoclonal antibody |
| Format | mab |
| Target Name | NF2 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-NF2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species MERL/ NF2/ ACN VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMAP000183 | Human NF2 Adenovirus particle |
| ORF Viral Vector | pGMAP000183 | Human NF2 Adenovirus plasmid |
| ORF Viral Vector | pGMAAV000184 | Norway rat Nf2 AAV plasmid |
| ORF Viral Vector | vGMAAV000184 | Norway rat Nf2 AAV particle |
Target information
| Target ID | GM-T95742 |
| Target Name | NF2 |
| Gene ID | 4771,18016,25744,714945,477535,101087787,540479,100058977 |
| Gene Symbol and Synonyms | ACN,BANF,merlin,merlin-1,NF2,SCH,SWNV |
| Uniprot Accession | P35240,Q63648 |
| Uniprot Entry Name | MERL_HUMAN,MERL_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000186575 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: NF2, gene name: NF2, also named as ACN, BANF, SCH. This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that link cytoskeletal components with proteins in the cell membrane. The encoded protein is involved in regulation of contact-dependent inhibition of cell proliferation and functions in cell-cell adhesion and transmembrane signaling. The encoded protein has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics, and proteins involved in regulating ion transport. Disruption of this protein's function has been implicated in tumorigenesis and metastasis. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. [provided by RefSeq, May 2022].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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