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Anti-ASIC3/ ACCN3/ DRASIC monoclonal antibody
Anti-ASIC3/ ACCN3/ DRASIC antibody for FACS & in-vivo assay
Go to ASIC3/ASIC3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T95947-Ab-1/ GM-Tg-hg-T95947-Ab-2 | Anti-Human ASIC3 monoclonal antibody | Human |
| GM-Tg-rg-T95947-Ab-1/ GM-Tg-rg-T95947-Ab-2 | Anti-Rat ASIC3 monoclonal antibody | Rat |
| GM-Tg-mg-T95947-Ab-1/ GM-Tg-mg-T95947-Ab-2 | Anti-Mouse ASIC3 monoclonal antibody | Mouse |
| GM-Tg-cynog-T95947-Ab-1/ GM-Tg-cynog-T95947-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ASIC3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T95947-Ab-1/ GM-Tg-felg-T95947-Ab-2 | Anti-Feline ASIC3 monoclonal antibody | Feline |
| GM-Tg-cang-T95947-Ab-1/ GM-Tg-cang-T95947-Ab-2 | Anti-Canine ASIC3 monoclonal antibody | Canine |
| GM-Tg-bovg-T95947-Ab-1/ GM-Tg-bovg-T95947-Ab-2 | Anti-Bovine ASIC3 monoclonal antibody | Bovine |
| GM-Tg-equg-T95947-Ab-1/ GM-Tg-equg-T95947-Ab-2 | Anti-Equine ASIC3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T95947-Ab-1/ GM-Tg-hg-T95947-Ab-2; GM-Tg-rg-T95947-Ab-1/ GM-Tg-rg-T95947-Ab-2; GM-Tg-mg-T95947-Ab-1/ GM-Tg-mg-T95947-Ab-2; GM-Tg-cynog-T95947-Ab-1/ GM-Tg-cynog-T95947-Ab-2; GM-Tg-felg-T95947-Ab-1/ GM-Tg-felg-T95947-Ab-2; GM-Tg-cang-T95947-Ab-1/ GM-Tg-cang-T95947-Ab-2; GM-Tg-bovg-T95947-Ab-1/ GM-Tg-bovg-T95947-Ab-2; GM-Tg-equg-T95947-Ab-1/ GM-Tg-equg-T95947-Ab-2 |
| Products Name | Anti-ASIC3 monoclonal antibody |
| Format | mab |
| Target Name | ASIC3 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-ASIC3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species ASIC3/ ACCN3/ DRASIC VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP003357 | human ASIC3 Lentivirus plasmid |
| ORF Viral Vector | vGMLP003357 | human ASIC3 Lentivirus particle |
| ORF Viral Vector | pGMLV000017 | rat Asic3 Lentivirus plasmid |
| ORF Viral Vector | vGMLV000017 | rat Asic3 Lentivirus particle |
Target information
| Target ID | GM-T95947 |
| Target Name | ASIC3 |
| Gene ID | 9311,171209,286920,714396,482801,101096970,789132,100063408 |
| Gene Symbol and Synonyms | ACCN3,ASIC3,DRASIC,SLNAC1,TNaC1 |
| Uniprot Accession | Q9UHC3,O35240 |
| Uniprot Entry Name | ASIC3_HUMAN,ASIC3_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000213199 |
| Target Classification | Ion Channel |
The target: ASIC3, gene name: ASIC3, also named as ACCN3, DRASIC, SLNAC1, TNaC1. This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 2 has been observed as proton-gated channels sensitive to gadolinium. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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