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Anti-GROA/ CXCL1/ FSP functional antibody
Anti-GROA/ CXCL1/ FSP functional antibody for cell culture, ELISA & in-vivo assay
Go to CXCL1/CXCL1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T96005-Ab-1/ GM-Tg-hg-T96005-Ab-2 | Anti-Human CXCL1 monoclonal antibody | Human |
| GM-Tg-rg-T96005-Ab-1/ GM-Tg-rg-T96005-Ab-2 | Anti-Rat CXCL1 monoclonal antibody | Rat |
| GM-Tg-mg-T96005-Ab-1/ GM-Tg-mg-T96005-Ab-2 | Anti-Mouse CXCL1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T96005-Ab-1/ GM-Tg-cynog-T96005-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CXCL1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T96005-Ab-1/ GM-Tg-felg-T96005-Ab-2 | Anti-Feline CXCL1 monoclonal antibody | Feline |
| GM-Tg-cang-T96005-Ab-1/ GM-Tg-cang-T96005-Ab-2 | Anti-Canine CXCL1 monoclonal antibody | Canine |
| GM-Tg-bovg-T96005-Ab-1/ GM-Tg-bovg-T96005-Ab-2 | Anti-Bovine CXCL1 monoclonal antibody | Bovine |
| GM-Tg-equg-T96005-Ab-1/ GM-Tg-equg-T96005-Ab-2 | Anti-Equine CXCL1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T96005-Ab-1/ GM-Tg-hg-T96005-Ab-2; GM-Tg-rg-T96005-Ab-1/ GM-Tg-rg-T96005-Ab-2; GM-Tg-mg-T96005-Ab-1/ GM-Tg-mg-T96005-Ab-2; GM-Tg-cynog-T96005-Ab-1/ GM-Tg-cynog-T96005-Ab-2; GM-Tg-felg-T96005-Ab-1/ GM-Tg-felg-T96005-Ab-2; GM-Tg-cang-T96005-Ab-1/ GM-Tg-cang-T96005-Ab-2; GM-Tg-bovg-T96005-Ab-1/ GM-Tg-bovg-T96005-Ab-2; GM-Tg-equg-T96005-Ab-1/ GM-Tg-equg-T96005-Ab-2 |
| Products Name | Anti-CXCL1 monoclonal antibody |
| Format | mab |
| Target Name | CXCL1 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CXCL1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T96005-Ag-1 | Recombinant multi-species GROA/ CXCL1/ FSP protein |
| Cytokine | GM-Tg-g-T96005-Ag-1 | chemokine (C-X-C motif) ligand 1 (CXCL1) protein |
| ORF Viral Vector | pGMLP000056 | human CXCL1 Lentivirus plasmid |
| ORF Viral Vector | vGMLP000056 | human CXCL1 Lentivirus particle |
| ORF Viral Vector | pGMLV000055 | rat Cxcl1 Lentivirus plasmid |
| ORF Viral Vector | pGMLV000549 | Norway rat Cxcl1 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm000908 | mouse Cxcl1 Lentivirus plasmid |
| ORF Viral Vector | vGMLV000055 | rat Cxcl1 Lentivirus particle |
| ORF Viral Vector | vGMLV000549 | Norway rat Cxcl1 Lentivirus particle |
| ORF Viral Vector | vGMLPm000908 | mouse Cxcl1 Lentivirus particle |
Target information
| Target ID | GM-T96005 |
| Target Name | CXCL1 |
| Gene ID | 2919,574222 |
| Gene Symbol and Synonyms | CXCL1,FSP,GRO1,GROa,MGSA,MGSA-a,NAP-3,SCYB1 |
| Uniprot Accession | P09341 |
| Uniprot Entry Name | GROA_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, Immuno-oncology Target, Cytokine Target |
| Disease | Prostate Cancer, Malignant neoplasm of bladder |
| Gene Ensembl | ENSG00000163739 |
| Target Classification | Checkpoint-Immuno Oncology |
The target: CXCL1, gene name: CXCL1, also named as FSP, GRO1, GROa, MGSA, MGSA-a, NAP-3, SCYB1. This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. Aberrant expression of this protein is associated with the growth and progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic activity. Alternate splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is found on chromosome 4. [provided by RefSeq, Sep 2014].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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