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Anti-GRIA4/ GLUR4/ GLUR4C monoclonal antibody
Anti-GRIA4/ GLUR4/ GLUR4C antibody for FACS & in-vivo assay
Go to GRIA4/GRIA4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T96235-Ab-1/ GM-Tg-hg-T96235-Ab-2 | Anti-Human GRIA4 monoclonal antibody | Human |
| GM-Tg-rg-T96235-Ab-1/ GM-Tg-rg-T96235-Ab-2 | Anti-Rat GRIA4 monoclonal antibody | Rat |
| GM-Tg-mg-T96235-Ab-1/ GM-Tg-mg-T96235-Ab-2 | Anti-Mouse GRIA4 monoclonal antibody | Mouse |
| GM-Tg-cynog-T96235-Ab-1/ GM-Tg-cynog-T96235-Ab-2 | Anti-Cynomolgus/ Rhesus macaque GRIA4 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T96235-Ab-1/ GM-Tg-felg-T96235-Ab-2 | Anti-Feline GRIA4 monoclonal antibody | Feline |
| GM-Tg-cang-T96235-Ab-1/ GM-Tg-cang-T96235-Ab-2 | Anti-Canine GRIA4 monoclonal antibody | Canine |
| GM-Tg-bovg-T96235-Ab-1/ GM-Tg-bovg-T96235-Ab-2 | Anti-Bovine GRIA4 monoclonal antibody | Bovine |
| GM-Tg-equg-T96235-Ab-1/ GM-Tg-equg-T96235-Ab-2 | Anti-Equine GRIA4 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T96235-Ab-1/ GM-Tg-hg-T96235-Ab-2; GM-Tg-rg-T96235-Ab-1/ GM-Tg-rg-T96235-Ab-2; GM-Tg-mg-T96235-Ab-1/ GM-Tg-mg-T96235-Ab-2; GM-Tg-cynog-T96235-Ab-1/ GM-Tg-cynog-T96235-Ab-2; GM-Tg-felg-T96235-Ab-1/ GM-Tg-felg-T96235-Ab-2; GM-Tg-cang-T96235-Ab-1/ GM-Tg-cang-T96235-Ab-2; GM-Tg-bovg-T96235-Ab-1/ GM-Tg-bovg-T96235-Ab-2; GM-Tg-equg-T96235-Ab-1/ GM-Tg-equg-T96235-Ab-2 |
| Products Name | Anti-GRIA4 monoclonal antibody |
| Format | mab |
| Target Name | GRIA4 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-GRIA4 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species GRIA4/ GLUR4/ GLUR4C VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-T96235 |
| Target Name | GRIA4 |
| Gene ID | 2893,14802,29629,705794,489427,101087003,529904,100061561 |
| Gene Symbol and Synonyms | GluA4,GluA4-ATD,Glur-4,GluR-D,GLUR4,GLUR4C,Gluralpha4,GLURD,GRIA4,NEDSGA,spkw1 |
| Uniprot Accession | P48058,P19493 |
| Uniprot Entry Name | GRIA4_HUMAN,GRIA4_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000152578 |
| Target Classification | N/A |
The target: GRIA4, gene name: GRIA4, also named as GLUR4, GLUR4C, GLURD, GluA4, NEDSGA. Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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