Anti-HK2 monoclonal antibody

Pre-made anti-HK2 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to HK2/HK2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T96685-Ab-1/ GM-Tg-hg-T96685-Ab-2Anti-Human HK2 monoclonal antibodyHuman
GM-Tg-rg-T96685-Ab-1/ GM-Tg-rg-T96685-Ab-2Anti-Rat HK2 monoclonal antibodyRat
GM-Tg-mg-T96685-Ab-1/ GM-Tg-mg-T96685-Ab-2Anti-Mouse HK2 monoclonal antibodyMouse
GM-Tg-cynog-T96685-Ab-1/ GM-Tg-cynog-T96685-Ab-2Anti-Cynomolgus/ Rhesus macaque HK2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T96685-Ab-1/ GM-Tg-felg-T96685-Ab-2Anti-Feline HK2 monoclonal antibodyFeline
GM-Tg-cang-T96685-Ab-1/ GM-Tg-cang-T96685-Ab-2Anti-Canine HK2 monoclonal antibodyCanine
GM-Tg-bovg-T96685-Ab-1/ GM-Tg-bovg-T96685-Ab-2Anti-Bovine HK2 monoclonal antibodyBovine
GM-Tg-equg-T96685-Ab-1/ GM-Tg-equg-T96685-Ab-2Anti-Equine HK2 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T96685-Ab-1/ GM-Tg-hg-T96685-Ab-2; GM-Tg-rg-T96685-Ab-1/ GM-Tg-rg-T96685-Ab-2;
GM-Tg-mg-T96685-Ab-1/ GM-Tg-mg-T96685-Ab-2; GM-Tg-cynog-T96685-Ab-1/ GM-Tg-cynog-T96685-Ab-2;
GM-Tg-felg-T96685-Ab-1/ GM-Tg-felg-T96685-Ab-2; GM-Tg-cang-T96685-Ab-1/ GM-Tg-cang-T96685-Ab-2;
GM-Tg-bovg-T96685-Ab-1/ GM-Tg-bovg-T96685-Ab-2; GM-Tg-equg-T96685-Ab-1/ GM-Tg-equg-T96685-Ab-2
Products NameAnti-HK2 monoclonal antibody
Formatmab
Target NameHK2
Protein Sub-locationIntrocelluar Protein
Category of antibodyTherapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-HK2 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-T96685-Ag-1Recombinant multi-species HXK2/ HK2/ HKII protein


    Target information

    Target IDGM-T96685
    Target NameHK2
    Gene ID3099,15277,25059,710479,100856448,101089344,788926,100009677
    Gene Symbol and SynonymsHK2,HKII,HXK2
    Uniprot AccessionP52789,P27881,A2PYL6
    Uniprot Entry NameHXK2_HUMAN,HXK2_RAT,HXK2_HORSE
    Protein Sub-locationIntrocelluar Protein
    CategoryTherapeutics Target
    DiseaseN/A
    Gene EnsemblENSG00000159399
    Target ClassificationN/A

    The target: HK2, gene name: HK2, also named as HKII, HXK2. Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells. [provided by RefSeq, Apr 2009].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.