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Anti-MCM7 monoclonal antibody
Pre-made anti-MCM7 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to MCM7/MCM7 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T96972-Ab-1/ GM-Tg-hg-T96972-Ab-2 | Anti-Human MCM7 monoclonal antibody | Human |
| GM-Tg-rg-T96972-Ab-1/ GM-Tg-rg-T96972-Ab-2 | Anti-Rat MCM7 monoclonal antibody | Rat |
| GM-Tg-mg-T96972-Ab-1/ GM-Tg-mg-T96972-Ab-2 | Anti-Mouse MCM7 monoclonal antibody | Mouse |
| GM-Tg-cynog-T96972-Ab-1/ GM-Tg-cynog-T96972-Ab-2 | Anti-Cynomolgus/ Rhesus macaque MCM7 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T96972-Ab-1/ GM-Tg-felg-T96972-Ab-2 | Anti-Feline MCM7 monoclonal antibody | Feline |
| GM-Tg-cang-T96972-Ab-1/ GM-Tg-cang-T96972-Ab-2 | Anti-Canine MCM7 monoclonal antibody | Canine |
| GM-Tg-bovg-T96972-Ab-1/ GM-Tg-bovg-T96972-Ab-2 | Anti-Bovine MCM7 monoclonal antibody | Bovine |
| GM-Tg-equg-T96972-Ab-1/ GM-Tg-equg-T96972-Ab-2 | Anti-Equine MCM7 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T96972-Ab-1/ GM-Tg-hg-T96972-Ab-2; GM-Tg-rg-T96972-Ab-1/ GM-Tg-rg-T96972-Ab-2; GM-Tg-mg-T96972-Ab-1/ GM-Tg-mg-T96972-Ab-2; GM-Tg-cynog-T96972-Ab-1/ GM-Tg-cynog-T96972-Ab-2; GM-Tg-felg-T96972-Ab-1/ GM-Tg-felg-T96972-Ab-2; GM-Tg-cang-T96972-Ab-1/ GM-Tg-cang-T96972-Ab-2; GM-Tg-bovg-T96972-Ab-1/ GM-Tg-bovg-T96972-Ab-2; GM-Tg-equg-T96972-Ab-1/ GM-Tg-equg-T96972-Ab-2 |
| Products Name | Anti-MCM7 monoclonal antibody |
| Format | mab |
| Target Name | MCM7 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-MCM7 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T96972-Ag-1 | Recombinant multi-species MCM7/ CDC47/ MCM2 protein |
| ORF Viral Vector | vGMAP000527 | human MCM7 Adenovirus particle |
| ORF Viral Vector | vGMLP002780 | human MCM7 Lentivirus particle |
| ORF Viral Vector | pGMLP002780 | human MCM7 Lentivirus plasmid |
| ORF Viral Vector | pGMAP000527 | human MCM7 Adenovirus plasmid |
Target information
| Target ID | GM-T96972 |
| Target Name | MCM7 |
| Gene ID | 4176,17220,288532,710766,119872149,101088383,539924,100068673 |
| Gene Symbol and Synonyms | CDC47,mCDC47,MCM2,MCM7,Mcmd7,P1.1-MCM3,P1CDC47,P85MCM,PNAS146,PPP1R104 |
| Uniprot Accession | P33993,Q3ZBH9 |
| Uniprot Entry Name | MCM7_HUMAN,MCM7_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000166508 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: MCM7, gene name: MCM7, also named as CDC47, MCM2, P1.1-MCM3, P1CDC47, P85MCM, PNAS146, PPP1R104. The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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