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Anti-FGF18/ FGF-18/ ZFGF5 functional antibody
Anti-FGF18/ FGF-18/ ZFGF5 functional antibody for cell culture, ELISA & in-vivo assay
Go to FGF18/FGF18 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T99732-Ab-1/ GM-Tg-hg-T99732-Ab-2 | Anti-Human FGF18 monoclonal antibody | Human |
| GM-Tg-rg-T99732-Ab-1/ GM-Tg-rg-T99732-Ab-2 | Anti-Rat FGF18 monoclonal antibody | Rat |
| GM-Tg-mg-T99732-Ab-1/ GM-Tg-mg-T99732-Ab-2 | Anti-Mouse FGF18 monoclonal antibody | Mouse |
| GM-Tg-cynog-T99732-Ab-1/ GM-Tg-cynog-T99732-Ab-2 | Anti-Cynomolgus/ Rhesus macaque FGF18 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T99732-Ab-1/ GM-Tg-felg-T99732-Ab-2 | Anti-Feline FGF18 monoclonal antibody | Feline |
| GM-Tg-cang-T99732-Ab-1/ GM-Tg-cang-T99732-Ab-2 | Anti-Canine FGF18 monoclonal antibody | Canine |
| GM-Tg-bovg-T99732-Ab-1/ GM-Tg-bovg-T99732-Ab-2 | Anti-Bovine FGF18 monoclonal antibody | Bovine |
| GM-Tg-equg-T99732-Ab-1/ GM-Tg-equg-T99732-Ab-2 | Anti-Equine FGF18 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T99732-Ab-1/ GM-Tg-hg-T99732-Ab-2; GM-Tg-rg-T99732-Ab-1/ GM-Tg-rg-T99732-Ab-2; GM-Tg-mg-T99732-Ab-1/ GM-Tg-mg-T99732-Ab-2; GM-Tg-cynog-T99732-Ab-1/ GM-Tg-cynog-T99732-Ab-2; GM-Tg-felg-T99732-Ab-1/ GM-Tg-felg-T99732-Ab-2; GM-Tg-cang-T99732-Ab-1/ GM-Tg-cang-T99732-Ab-2; GM-Tg-bovg-T99732-Ab-1/ GM-Tg-bovg-T99732-Ab-2; GM-Tg-equg-T99732-Ab-1/ GM-Tg-equg-T99732-Ab-2 |
| Products Name | Anti-FGF18 monoclonal antibody |
| Format | mab |
| Target Name | FGF18 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-FGF18 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T99732-Ag-1 | Recombinant multi-species FGF18/ FGF-18/ ZFGF5 protein |
| Cytokine | GM-Tg-g-T99732-Ag-1 | fibroblast growth factor 18 (FGF18) protein |
| ORF Viral Vector | pGMLP000468 | human FGF18 Lentivirus plasmid |
| ORF Viral Vector | vGMAP000362 | Human FGF18 Adenovirus particle |
| ORF Viral Vector | vGMLP000468 | human FGF18 Lentivirus particle |
| ORF Viral Vector | pGMAP000362 | Human FGF18 Adenovirus plasmid |
| ORF Viral Vector | pGMLPm004509 | mouse Fgf18 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004509 | mouse Fgf18 Lentivirus particle |
Target information
| Target ID | GM-T99732 |
| Target Name | FGF18 |
| Gene ID | 8817,14172,29369,702072,611641,101098518,533929,100629648 |
| Gene Symbol and Synonyms | D130055P09Rik,FGF-18,FGF18,Fgf6a,ZFGF5 |
| Uniprot Accession | O76093,O88182,Q0VCA0 |
| Uniprot Entry Name | FGF18_HUMAN,FGF18_RAT,FGF18_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, Cytokine Target |
| Disease | Breast Cancer |
| Gene Ensembl | ENSG00000156427 |
| Target Classification | N/A |
The target: FGF18, gene name: FGF18, also named as FGF-18, ZFGF5. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Knockout studies of the similar gene in mice implied the role of this protein in regulating proliferation and differentiation of midline cerebellar structures. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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