Anti-RNASEH2C monoclonal antibody
Pre-made anti-RNASEH2C monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-TA154-Ab-1/ GM-Tg-hg-TA154-Ab-2 | Anti-Human RNASEH2C monoclonal antibody | Human |
GM-Tg-rg-TA154-Ab-1/ GM-Tg-rg-TA154-Ab-2 | Anti-Rat RNASEH2C monoclonal antibody | Rat |
GM-Tg-mg-TA154-Ab-1/ GM-Tg-mg-TA154-Ab-2 | Anti-Mouse RNASEH2C monoclonal antibody | Mouse |
GM-Tg-cynog-TA154-Ab-1/ GM-Tg-cynog-TA154-Ab-2 | Anti-Cynomolgus/ Rhesus macaque RNASEH2C monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-TA154-Ab-1/ GM-Tg-felg-TA154-Ab-2 | Anti-Feline RNASEH2C monoclonal antibody | Feline |
GM-Tg-cang-TA154-Ab-1/ GM-Tg-cang-TA154-Ab-2 | Anti-Canine RNASEH2C monoclonal antibody | Canine |
GM-Tg-bovg-TA154-Ab-1/ GM-Tg-bovg-TA154-Ab-2 | Anti-Bovine RNASEH2C monoclonal antibody | Bovine |
GM-Tg-equg-TA154-Ab-1/ GM-Tg-equg-TA154-Ab-2 | Anti-Equine RNASEH2C monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-TA154-Ab-1/ GM-Tg-hg-TA154-Ab-2; GM-Tg-rg-TA154-Ab-1/ GM-Tg-rg-TA154-Ab-2; GM-Tg-mg-TA154-Ab-1/ GM-Tg-mg-TA154-Ab-2; GM-Tg-cynog-TA154-Ab-1/ GM-Tg-cynog-TA154-Ab-2; GM-Tg-felg-TA154-Ab-1/ GM-Tg-felg-TA154-Ab-2; GM-Tg-cang-TA154-Ab-1/ GM-Tg-cang-TA154-Ab-2; GM-Tg-bovg-TA154-Ab-1/ GM-Tg-bovg-TA154-Ab-2; GM-Tg-equg-TA154-Ab-1/ GM-Tg-equg-TA154-Ab-2 |
Products Name | Anti-RNASEH2C monoclonal antibody |
Format | mab |
Target Name | RNASEH2C |
Protein Sub-location | Introcelluar Protein |
Category of antibody | Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
Tag | Fc |
Products description | Pre-made anti-RNASEH2C monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation | Lyophilized from sterile PBS, PH 7.4 |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | GM-Tg-g-TA154-Ag-1 | Recombinant multi-species RNH2C/ RNASEH2C/ AGS3 protein |
ORF Viral Vector | vGMAP000510 | Human RNASEH2C Adenovirus particle |
ORF Viral Vector | pGMAP000510 | Human RNASEH2C Adenovirus plasmid |
Target information
Target ID | GM-TA154 |
Target Name | RNASEH2C |
Gene ID | 84153,68209,100361939,700330,610886,101100003,505618,100057522 |
Gene Symbol and Synonyms | 1500026D16Rik,AGS3,AYP1,RNASEH2C |
Uniprot Accession | Q8TDP1,Q2M2U4 |
Uniprot Entry Name | RNH2C_HUMAN,RNH2C_BOVIN |
Protein Sub-location | Introcelluar Protein |
Category | Therapeutics Target |
Disease | N/A |
Gene Ensembl | ENSG00000172922 |
Target Classification | N/A |
The target: RNASEH2C, gene name: RNASEH2C, also named as AGS3, AYP1. This gene encodes a ribonuclease H subunit that can cleave ribonucleotides from RNA:DNA duplexes. Mutations in this gene cause Aicardi-Goutieres syndrome-3, a disease that causes severe neurologic dysfunction. A pseudogene for this gene has been identified on chromosome Y, near the sex determining region Y (SRY) gene. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.