Equine Pancreatic elastase (PE-1) antibody and antigen (recombinant protein)

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Diagnostic anti-Equine Pancreatic elastase (PE-1) antibodies pairs and antigen for animal health (animal Equine/Horse pancreatitis) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Validation Data

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Target/Biomarker Information

Pancreatic Elastase, an enzymatic workhorse produced by the exocrine pancreas, occupies a pivotal role in the intricate symphony of protein digestion. Structurally, it belongs to the serine protease family, characterized by a catalytic triad composed of serine, histidine, and aspartate residues. The active site of pancreatic elastase is finely tuned to cleave peptide bonds adjacent to small, hydrophobic amino acids, making it particularly suited for its primary substrate, elastin.

Elastin, a structural protein, bestows elasticity upon various connective tissues, including arteries, skin, and organs. The digestion of elastin and other proteins is catalyzed by pancreatic elastase, which cleaves these macromolecules into smaller, more manageable peptide fragments. This process is instrumental in breaking down dietary proteins into amino acids, the building blocks of life, enabling their absorption in the small intestine.

Pancreatic elastase's release into the duodenum and upper jejunum of the small intestine is meticulously regulated in response to hormonal signals, ensuring that it is deployed precisely when needed during the digestive process.

The measurement of pancreatic elastase levels offers a glimpse into the pancreas's exocrine function. A decrease in pancreatic elastase levels below the normative range signifies impaired pancreatic function and a compromised ability to digest proteins. This can lead to the malabsorption of essential nutrients and the development of clinical symptoms associated with protein deficiency.

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