Folate(folic acid,FA) antibody/antigen (BSA/OVA/KLH conjugated hapten)

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anti-Folate(folic acid,FA) antibody and Carrier-coupled antigen/immunogen (hapten-carrier conjugates)

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Product information

Size： 1mg | 10mg | 100mg

Product Description

BSA-Folate(folic acid,FA)

OVA-Folate(folic acid,FA)

Anti-Folate(folic acid,FA) mouse monoclonal antibody

Anti-Folate(folic acid,FA) human monoclonal antibody

Reference

Validation Data

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Biomarker Information

1. Folate (Folic Acid, FA): Folate, also known as folic acid or FA, is a fundamental water-soluble B-vitamin, specifically referred to as vitamin B9. Its indispensability in human physiology arises from its multifaceted involvement in various metabolic pathways. In the context of in vitro diagnosis (IVD), understanding the critical roles of folate becomes paramount.

Folate operates primarily as a co-factor in one-carbon metabolism, a central biochemical process that regulates the transfer of single-carbon units. This metabolic function plays a pivotal role in several critical cellular processes, with particular relevance to DNA synthesis, repair, and methylation. These processes are integral for the maintenance of genomic stability, gene expression regulation, and cell division.

2. Significance of Folate Measurement:

a. Nutritional Assessment: The measurement of folate levels serves as a vital tool for evaluating an individual's nutritional status. Folate deficiency can result in the development of macrocytic anemia, characterized by enlarged red blood cells. This condition can lead to fatigue, weakness, and other symptoms associated with anemia. Of significant concern is the impact of folate deficiency during pregnancy, where it heightens the risk of neural tube defects in the developing fetus. Adequate folate levels are crucial for preventing these birth defects, making precise measurements imperative for expectant mothers.

b. Health Condition Monitoring: Individuals afflicted with medical conditions that affect folate metabolism, such as malabsorption syndromes, celiac disease, or renal diseases, require regular folate monitoring. By doing so, healthcare providers can ensure that these patients receive appropriate care and interventions to manage their specific health needs. Timely detection and management of folate deficiencies in these contexts can prevent complications and improve overall health outcomes.

c. Pregnancy and Fetal Development: Folate's role in preventing neural tube defects is well-established, making its measurement crucial during pregnancy. The neural tube is the embryonic structure that develops into the brain and spinal cord. Folate is essential for proper neural tube closure in the early stages of pregnancy. Monitoring folate levels in expectant mothers ensures that they maintain adequate folate levels, reducing the risk of neural tube defects in their unborn children. It underscores the importance of folate supplementation, especially during the critical early stages of pregnancy when neural tube development occurs.

d. Medication Management: Some medications, including certain anti-epileptic drugs and methotrexate (used in cancer treatment and autoimmune diseases), can interfere with folate metabolism. Methotrexate, in particular, inhibits the enzyme responsible for converting folate into its active form, thus potentially leading to folate deficiency. Monitoring folate levels in patients taking these medications is essential to mitigate potential adverse effects. Healthcare providers can adjust treatment plans, prescribe folate supplementation, or explore alternative therapies to minimize the impact on folate metabolism while ensuring the effectiveness of the prescribed medications.

e. Personalized Healthcare: Accurate folate measurements provide healthcare providers with valuable insights into an individual's specific folate-related health needs. This information facilitates personalized treatment plans that address the unique requirements of each patient. Depending on the measurement results, healthcare professionals can recommend dietary adjustments, prescribe folate supplements, or modify medication regimens. Personalized care tailored to an individual's folate status can significantly enhance treatment efficacy, patient well-being, and overall health outcomes.

In summary, the measurement of folate (folic acid, FA) holds paramount importance in various aspects of healthcare, including nutritional assessment, health condition monitoring, pregnancy care, medication management, and the delivery of personalized healthcare. Its intricate involvement in critical cellular processes underscores its significance in diagnosing and managing various medical conditions, ensuring the health of expectant mothers and their unborn children, and optimizing overall health and well-being. Accurate folate measurements empower healthcare providers with valuable information to make informed decisions, ultimately contributing to better patient outcomes and quality of life.

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