Rickettsia raoultii antibody and antigen (recombinant protein)

Diagnostic anti-Rickettsia raoultii antibodies pairs and antigen for animal health (animal Dog/Canine infectious disease spotted fever group Rickettsia) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No. Description US $ Price (per mg)
GMP-VT-P038-Tg001-Ag01 Recombinant Rickettsia raoultii protein $3090.00
GMP-VT-P038-Tg001-Ab01 Anti-Rickettsia raoultii mouse monoclonal antibody (mAb) $3090.00
GMP-VT-P038-Tg001-Ab02 Anti-Rickettsia raoultii mouse monoclonal antibody (mAb) $3090.00
GMP-VT-P038-Tg001-Ab03 Anti-Rickettsia raoultii human monoclonal antibody (mAb) $3090.00
GMP-VT-P038-Tg001-Ab04 Anti-Rickettsia raoultii human monoclonal antibody (mAb) $3090.00

Size: 1mg | 10mg | 100mg



Product Description

Cat No. GMP-VT-P038-Tg001-Ag01
Product Name Recombinant Rickettsia raoultii protein
Pathogen Rickettsia raoultii
Expression platform E.coli
Isotypes Recombinant Antigen
Bioactivity validation Anti-Rickettsia raoultii antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Rickettsia raoultii level test of animal Dog/Canine infectious disease with spotted fever group Rickettsia.
Tag His
Product description Recombinant Rickettsia raoultii proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity Purity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No. GMP-VT-P038-Tg001-Ab01,GMP-VT-P038-Tg001-Ab02
Pathogen Rickettsia raoultii
Product Name Anti-Rickettsia raoultii mouse monoclonal antibody (mAb)
Expression platform CHO
Isotypes Mouse IgG
Bioactivity validation Recombinant Rickettsia raoultii antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Rickettsia raoultii antibodies in Rickettsia raoultii level test of animal Dog/Canine infectious disease with spotted fever group Rickettsia.
Product description Anti-Rickettsia raoultii mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Rickettsia raoultii antibodies.
Purity Purity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No. GMP-VT-P038-Tg001-Ab03,GMP-VT-P038-Tg001-Ab04
Pathogen Rickettsia raoultii
Product Name Anti-Rickettsia raoultii human monoclonal antibody (mAb)
Expression platform CHO
Isotypes Human lgG1
Bioactivity validation Recombinant Rickettsia raoultii antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Rickettsia raoultii antibodies in Rickettsia raoultii level test of animal Dog/Canine infectious disease with spotted fever group Rickettsia.
Product description Anti-Rickettsia raoultii mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity Purity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


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    Pathogen Information


    Rickettsia raoultii is a tick-borne bacterial pathogen that primarily infects small mammals such as rodents and shrews. However, humans can also acquire the infection through tick bites, and it has been reported in several countries worldwide, including China, Mongolia, Russia, and Korea.

    The bacterium belongs to the family Rickettsiaceae and is a gram-negative, obligate intracellular bacterium. It is considered an emerging pathogen and has been recognized as the causative agent of several cases of human spotted fever in Europe and Asia. Rickettsia raoultii infection in humans typically presents with flu-like symptoms such as fever, headache, muscle aches, and a rash that appears on the extremities.

    Rickettsia raoultii has a genome size of approximately 1.5 Mb and encodes for various genes and proteins that are essential for its survival and virulence. Some of the key genes and proteins encoded by Rickettsia raoultii include outer membrane protein A (OmpA), outer membrane protein B (OmpB), and citrate synthase (GltA). The OmpA protein is involved in adhesion to host cells and the evasion of host immune responses. The OmpB protein is important for the bacterium's invasive properties and plays a role in the formation of a protective coating around the bacterium. Citrate synthase (GltA) is a key enzyme in the citric acid cycle and is essential for the bacterium's energy metabolism.

    Rickettsia raoultii is an obligate intracellular bacterium, which means that it requires host cells to replicate. The bacterium enters host cells through a process called phagocytosis, where the bacterium is engulfed by the host cell and enclosed in a membrane-bound compartment called the phagosome. Once inside the phagosome, the bacterium is able to escape into the host cell's cytoplasm and replicate.

    Diagnostic methods for Rickettsia raoultii infection include serological assays, which detect the presence of antibodies against the bacterium in patient serum. Direct detection of the bacterium's DNA can be achieved using polymerase chain reaction (PCR)-based assays that target specific genes such as gltA and ompA. In addition, indirect immunofluorescence assays (IFA) and enzyme-linked immunosorbent assays (ELISA) can detect the presence of specific proteins such as OmpA and OmpB. These diagnostic methods are critical for accurate and timely identification of Rickettsia raoultii infection in both humans and animals.

    In addition to causing spotted fever in humans, Rickettsia raoultii has been identified as a potential zoonotic pathogen, with evidence of infection in a variety of animal species including rodents, shrews, and several domesticated animals such as dogs, cats, horses, and cows. This highlights the importance of surveillance and monitoring of animal populations for the presence of Rickettsia raoultii infection.

    Control and prevention of Rickettsia raoultii infection primarily involves tick control measures, including the use of acaricides, regular inspection of pets, and avoiding areas where ticks are prevalent. In addition, early diagnosis and appropriate treatment with antibiotics such as doxycycline or azithromycin are essential for successful treatment of Rickettsia raoultii infection.

    In conclusion, Rickettsia raoultii is an emerging tick-borne bacterial pathogen that can cause spotted fever in humans. The bacterium primarily infects small mammals but has also been identified in several domesticated animals. Diagnostic methods for Rickettsia raoultii infection include serological assays, PCR-based assays, and ELISA/IFA assays. Control and prevention of Rickettsia raoultii infection involve tick control measures and early diagnosis and appropriate treatment with antibiotics.



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