Nipah virus NP Glycoproteins (F and G) M protein antibody and antigen (recombinant protein)

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Diagnostic anti-Nipah virus NP Glycoproteins (F and G) M protein antibodies pairs and antigen for animal health (animal Swine/Porcine/Pig infectious disease Nipah virus infection) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-VT-P134-Tg001-Ag01	Recombinant Nipah virus NP Glycoproteins (F and G) M protein protein	$3090.00
GMP-VT-P134-Tg001-Ab01	Anti-Nipah virus NP Glycoproteins (F and G) M protein mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P134-Tg001-Ab02	Anti-Nipah virus NP Glycoproteins (F and G) M protein mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P134-Tg001-Ab03	Anti-Nipah virus NP Glycoproteins (F and G) M protein human monoclonal antibody (mAb)	$3090.00
GMP-VT-P134-Tg001-Ab04	Anti-Nipah virus NP Glycoproteins (F and G) M protein human monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-VT-P134-Tg001-Ag01
Product Name	Recombinant Nipah virus NP Glycoproteins (F and G) M protein protein
Pathogen	Nipah virus
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Nipah virus NP Glycoproteins (F and G) M protein antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Nipah virus level test of animal Swine/Porcine/Pig infectious disease with Nipah virus infection.
Tag	His
Product description	Recombinant Nipah virus NP Glycoproteins (F and G) M protein proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P134-Tg001-Ab01,GMP-VT-P134-Tg001-Ab02
Pathogen	Nipah virus
Product Name	Anti-Nipah virus NP Glycoproteins (F and G) M protein mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Nipah virus NP Glycoproteins (F and G) M protein antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Nipah virus antibodies in Nipah virus level test of animal Swine/Porcine/Pig infectious disease with Nipah virus infection.
Product description	Anti-Nipah virus NP Glycoproteins (F and G) M protein mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Nipah virus antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P134-Tg001-Ab03,GMP-VT-P134-Tg001-Ab04
Pathogen	Nipah virus
Product Name	Anti-Nipah virus NP Glycoproteins (F and G) M protein human monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	Recombinant Nipah virus NP Glycoproteins (F and G) M protein antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Nipah virus antibodies in Nipah virus level test of animal Swine/Porcine/Pig infectious disease with Nipah virus infection.
Product description	Anti-Nipah virus NP Glycoproteins (F and G) M protein mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Pathogen Information

Nipah Virus (NiV): An In-Depth Overview

Introduction:

The Nipah virus (NiV) is a formidable zoonotic pathogen belonging to the Paramyxoviridae family. It is distinguished as a negative-sense, single-stranded RNA virus, and its significance lies in the severe respiratory and neurological diseases it induces in humans. This comprehensive overview delves into the taxonomy, structure, hosts, diseases, and diagnostic methods associated with the Nipah virus.

Taxonomy and Classification:

Nipah virus is classified as a virus, more specifically as a member of the Paramyxoviridae family. This family encompasses a diverse group of viruses known for their distinctive features. Paramyxoviruses are enveloped viruses with non-segmented, negative-sense RNA genomes. The taxonomy of Nipah virus places it within the Henipavirus genus alongside the closely related Hendra virus, collectively known as henipaviruses.

Pathogen Structure:

The Nipah virus boasts a highly structured morphology, comprising an enveloped virion with a helical nucleocapsid. Essential genetic and protein elements of the virus include:

Main Gene: The genome of Nipah virus encodes several vital genes, which orchestrate the replication and pathogenesis of the virus. Notable among them are the nucleocapsid (N), phosphoprotein (P), matrix (M), fusion (F), glycoprotein (G), and RNA-dependent RNA polymerase (L) genes.

Main Protein: Among the structural proteins, the N protein stands out for its pivotal role. The N protein plays a crucial function in encapsidating the viral RNA, facilitating viral replication, and orchestrating the assembly of progeny virions. Its interactions with other viral proteins are essential for viral survival and pathogenesis.

Hosts Infected by the Pathogen:

The Nipah virus exhibits a multi-faceted host range, which is integral to its transmission dynamics. The primary reservoir host for Nipah virus is fruit bats of the Pteropodidae family. These bats are natural hosts and carriers of the virus, although they typically do not manifest clinical symptoms. However, the virus can spill over into other animal species and humans, where it can lead to diseases of varying severity.

Diseases Associated with Nipah Virus:

Nipah virus infection can manifest as a range of diseases, affecting both animals and humans. In humans, two distinctive clinical syndromes emerge:

Nipah Fever: This syndrome presents as an acute febrile illness with symptoms like fever, headache, muscle pain, vomiting, and sore throat. These initial flu-like symptoms can rapidly progress to severe respiratory distress.

Nipah Encephalitis: Nipah encephalitis is the more severe and notorious form of the disease. It involves inflammation of the brain and is characterized by altered consciousness, seizures, and often a fatal outcome. Neurological signs are predominant in patients suffering from this form of Nipah virus infection.

In animals, Nipah virus can cause respiratory and neurological symptoms, with the severity of the disease varying among different species. Infections in pigs can lead to respiratory illness, while in horses, it can result in a syndrome similar to that seen in humans.

Diagnostic Methods:

Early and accurate diagnosis of Nipah virus infection is of paramount importance for effective disease management and outbreak control. Several diagnostic methods are employed, including:

Polymerase Chain Reaction (PCR): PCR techniques are vital for the detection of Nipah virus genetic material. Specific genes targeted for amplification include the N, P, or L genes of the virus. This molecular method provides rapid and precise identification of the virus.

Enzyme-Linked Immunosorbent Assay (ELISA): ELISA assays are utilized to detect Nipah virus proteins, such as the N or G proteins. These tests enable the quantification of viral proteins, aiding in diagnosis and research.

Virus Isolation: Isolating the virus from clinical samples and subsequent culture and characterization play a crucial role in confirming Nipah virus infections. This method involves growing the virus in suitable cell lines under controlled laboratory conditions.

Serological Tests: Serological tests detect the presence of antibodies produced in response to Nipah virus infection. These tests are essential for assessing the exposure of individuals and populations to the virus and can help in epidemiological investigations.

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