Infectious Bronchitis Virus - Variant Arkansas antibody and antigen (recombinant protein)

Diagnostic anti-Infectious Bronchitis Virus - Variant Arkansas antibodies pairs and antigen for animal health (animal Avian/Bird/Poultry infectious disease respiratory disease) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No. Description US $ Price (per mg)
GMP-VT-P151-Ag01 Recombinant Infectious Bronchitis Virus - Variant Arkansas protein $3090.00
GMP-VT-P151-Ab01 Anti-Infectious Bronchitis Virus - Variant Arkansas mouse monoclonal antibody (mAb) $3090.00
GMP-VT-P151-Ab02 Anti-Infectious Bronchitis Virus - Variant Arkansas mouse monoclonal antibody (mAb) $3090.00

Size: 1mg | 10mg | 100mg



Product Description

Cat No. GMP-VT-P151-Ag01
Product Name Recombinant Infectious Bronchitis Virus - Variant Arkansas protein
Pathogen Infectious Bronchitis Virus - Variant Arkansas
Expression platform E.coli
Isotypes Recombinant Antigen
Bioactivity validation Anti-Infectious Bronchitis Virus - Variant Arkansas antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Infectious Bronchitis Virus - Variant Arkansas level test of animal Avian/Bird/Poultry infectious disease with respiratory disease.
Tag His
Product description Recombinant Infectious Bronchitis Virus - Variant Arkansas proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity Purity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No. GMP-VT-P151-Ab01,GMP-VT-P151-Ab02
Pathogen Infectious Bronchitis Virus - Variant Arkansas
Product Name Anti-Infectious Bronchitis Virus - Variant Arkansas mouse monoclonal antibody (mAb)
Expression platform CHO
Isotypes Mouse IgG
Bioactivity validation Recombinant Infectious Bronchitis Virus - Variant Arkansas antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Infectious Bronchitis Virus - Variant Arkansas antibodies in Infectious Bronchitis Virus - Variant Arkansas level test of animal Avian/Bird/Poultry infectious disease with respiratory disease.
Product description Anti-Infectious Bronchitis Virus - Variant Arkansas mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Infectious Bronchitis Virus - Variant Arkansas antibodies./td>
Purity Purity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Reference




    Validation Data


    Click to get more Data / Case study about the product.



    Pathogen


    Infectious Bronchitis Virus (IBV) is a highly contagious RNA virus that primarily affects poultry birds, including chickens, turkeys, and quails. The virus was first reported in the United States in the 1930s and has since been distributed globally, causing significant economic losses in the poultry industry worldwide.

    The virus belongs to the Coronaviridae family, which contains other notorious pathogens with immense public health implications, such as Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), Middle East Respiratory Syndrome Coronavirus (MERS-CoV), and the current COVID-19 pandemic caused by SARS-CoV-2. Like other coronaviruses, IBV possesses a single-stranded RNA genome enclosed in a lipid envelope and a nucleocapsid composed of multiple copies of nucleoproteins.

    IBV exhibits a high degree of genetic diversity, with multiple variants identified worldwide, each with its unique pathogenicity and tissue tropism. The Arkansas variant of IBV is prevalent in various parts of the world, including Europe, Asia, and the Americas, causing significant morbidity and mortality in chicken flocks, particularly among younger birds.

    The pathogenicity of IBV is associated with the spike (S) protein, which is responsible for viral entry and binding to receptor molecules on the surface of host cells. The S protein comprises two domains: the S1 domain, which recognizes and binds to host cell receptors, and the S2 domain, which mediates viral fusion with the host cell membrane, allowing for entry into the cell.

    IBV infects the respiratory tract of birds, leading to tracheitis, bronchitis, and pneumonia. Clinical signs of IBV infection include coughing, sneezing, nasal discharge, and swollen sinuses. In severe cases, the virus may lead to mortality, particularly among younger birds with weakened immune systems. Besides respiratory signs, IBV may also infect the urogenital and gastrointestinal tracts, resulting in renal failure, infertility, and decreased egg production.

    Effective detection and control of IBV require accurate and reliable diagnostic methods. Traditionally, virus isolation or serology-based assays, such as the Haemagglutination Inhibition (HI) Test, have been widely used for IBV diagnosis. More recently, nucleic acid-based techniques, including Reverse Transcription Polymerase Chain Reaction (RT-PCR) and Real-Time PCR (qPCR), have become widely used due to their superior sensitivity and specificity. These molecular methods amplify segments of the viral genome, including the S gene, allowing for the early detection of IBV infections.

    In conclusion, IBV is a highly infectious and genetically diverse virus that affects primarily poultry birds worldwide, causing respiratory, renal, and reproductive tract damage, leading to significant economic losses in the poultry industry. The Arkansas variant of IBV, in particular, has garnered attention due to its high pathogenicity among chicken flocks. Early and accurate detection of IBV infections through molecular diagnostic methods is crucial for effective control measures, including vaccination and biosecurity practices, to minimize its spread and impact on the poultry industry.



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