Avian Influenza Virus Type A H7N2 subtype HA antibody and antigen (recombinant protein)

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Diagnostic anti-Avian Influenza Virus Type A H7N2 subtype HA antibodies pairs and antigen for animal health (animal Avian/Bird/Poultry infectious disease Avian influenza) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-VT-P187-Tg002-Ag01	Recombinant Avian Influenza Virus Type A H7N2 subtype HA protein	$3090.00
GMP-VT-P187-Tg002-Ab01	Anti-Avian Influenza Virus Type A H7N2 subtype HA mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P187-Tg002-Ab02	Anti-Avian Influenza Virus Type A H7N2 subtype HA mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P187-Tg002-Ab03	Anti-Avian Influenza Virus Type A H7N2 subtype HA human monoclonal antibody (mAb)	$3090.00
GMP-VT-P187-Tg002-Ab04	Anti-Avian Influenza Virus Type A H7N2 subtype HA human monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-VT-P187-Tg002-Ag01
Product Name	Recombinant Avian Influenza Virus Type A H7N2 subtype HA protein
Pathogen	Avian Influenza Virus Type A H7N2 subtype
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Avian Influenza Virus Type A H7N2 subtype HA antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Avian Influenza Virus Type A H7N2 subtype level test of animal Avian/Bird/Poultry infectious disease with Avian influenza.
Tag	His
Product description	Recombinant Avian Influenza Virus Type A H7N2 subtype HA proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P187-Tg002-Ab01,GMP-VT-P187-Tg002-Ab02
Pathogen	Avian Influenza Virus Type A H7N2 subtype
Product Name	Anti-Avian Influenza Virus Type A H7N2 subtype HA mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Avian Influenza Virus Type A H7N2 subtype HA antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Avian Influenza Virus Type A H7N2 subtype antibodies in Avian Influenza Virus Type A H7N2 subtype level test of animal Avian/Bird/Poultry infectious disease with Avian influenza.
Product description	Anti-Avian Influenza Virus Type A H7N2 subtype HA mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Avian Influenza Virus Type A H7N2 subtype antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P187-Tg002-Ab03,GMP-VT-P187-Tg002-Ab04
Pathogen	Avian Influenza Virus Type A H7N2 subtype
Product Name	Anti-Avian Influenza Virus Type A H7N2 subtype HA human monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	Recombinant Avian Influenza Virus Type A H7N2 subtype HA antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Avian Influenza Virus Type A H7N2 subtype antibodies in Avian Influenza Virus Type A H7N2 subtype level test of animal Avian/Bird/Poultry infectious disease with Avian influenza.
Product description	Anti-Avian Influenza Virus Type A H7N2 subtype HA mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Pathogen Information

Introduction to Avian Influenza Virus Type A H7N2:

Avian Influenza Virus Type A H7N2 is a subtype of the Influenza A virus, a member of the Orthomyxoviridae family. This particular subtype is of significant interest due to its ability to infect avian species, especially poultry, and its occasional zoonotic potential, causing infections in humans. In this comprehensive overview, we will delve into the classification, structure, hosts, associated diseases, and diagnostic methods related to Avian Influenza Virus Type A H7N2.

Classification:

Avian Influenza Virus Type A H7N2 is classified as a virus, specifically an influenza A virus. It belongs to the Orthomyxoviridae family, which comprises segmented, negative-sense single-stranded RNA viruses. Influenza A viruses are known for their high mutation rate, leading to the emergence of new strains and subtypes, which can pose challenges for vaccine development and control.

Viral Structure:

This virus possesses a complex structure with a lipid bilayer envelope derived from the host cell membrane. The genetic material of Avian Influenza Virus Type A H7N2 is composed of eight separate RNA segments, each encoding different viral proteins. Two of the most crucial components are the hemagglutinin (H) and neuraminidase (N) surface glycoproteins, which play vital roles in the virus's ability to attach to host cells, enter them, and exit after replication. The H7N2 subtype is named after these surface proteins, with "H" representing hemagglutinin and "N" representing neuraminidase.

Hosts and Associated Diseases:

The primary reservoir for Avian Influenza Virus Type A H7N2 is avian species, particularly domestic and wild birds. Poultry, including chickens and turkeys, are common hosts. However, what makes this subtype particularly noteworthy is its zoonotic potential. Although human infections are sporadic, they do occur. Human infections are often linked to direct or close contact with infected birds, particularly in settings like live poultry markets.

In avian hosts, infection with Avian Influenza Virus Type A H7N2 can lead to a spectrum of diseases collectively referred to as avian influenza. The severity of these diseases can vary widely, with some birds remaining asymptomatic carriers while others suffer severe respiratory and gastrointestinal symptoms. In cases where the virus infects humans, the clinical presentation often resembles that of seasonal influenza, with symptoms including fever, cough, sore throat, muscle aches, and fatigue. However, some individuals may develop more severe respiratory complications, leading to pneumonia and, in rare cases, death.

Diagnostic Methods:

The timely and accurate detection of Avian Influenza Virus Type A H7N2 is crucial for the effective management and control of potential outbreaks. Several diagnostic methods are employed for this purpose:

Nucleic Acid-based Methods: These methods, including Polymerase Chain Reaction (PCR) and Real-time PCR, are highly specific and sensitive. They target conserved regions within the viral RNA segments, such as those encoding hemagglutinin (H) and neuraminidase (N). These tests are instrumental in confirming the presence of the virus in clinical samples.

Viral Culture: Isolation and propagation of the virus in cell culture is another diagnostic approach. This method allows for the virus to be identified and further characterized, aiding in epidemiological studies and vaccine development.

Serological Tests: Enzyme-Linked Immunosorbent Assays (ELISA) and Hemagglutination Inhibition (HI) assays are serological tests used to detect antibodies against viral proteins, particularly hemagglutinin (H). These tests can be valuable for assessing previous exposure to the virus in both avian and human populations.

Sequencing and Phylogenetic Analysis: Genetic sequencing of the virus is essential for understanding its evolutionary history and tracking changes in its genome over time. Phylogenetic analysis helps trace the origins and potential sources of infections.

Epidemiological Surveillance: Monitoring the movement of birds, especially migratory species, and conducting regular surveillance of poultry farms and live bird markets are essential components of preventing and controlling the spread of Avian Influenza Virus Type A H7N2.

Conclusion:

Avian Influenza Virus Type A H7N2, as a subtype of the Influenza A virus, is a pathogen of concern due to its impact on both avian and human health. Understanding its classification, structure, hosts, associated diseases, and diagnostic methods is pivotal for effective surveillance, prevention, and control. Research into this virus continues, with a focus on monitoring its evolution and improving diagnostic tools to protect both poultry and human populations from potential outbreaks and zoonotic transmission.

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