Avian Influenza Virus Type A H7N7 subtype antibody and antigen (recombinant protein)

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Diagnostic anti-Avian Influenza Virus Type A H7N7 subtype antibodies pairs and antigen for animal health (animal Avian/Bird/Poultry infectious disease Avian influenza) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-VT-P188-Ag01	Recombinant Avian Influenza Virus Type A H7N7 subtype protein	$3090.00
GMP-VT-P188-Ab01	Anti-Avian Influenza Virus Type A H7N7 subtype mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P188-Ab02	Anti-Avian Influenza Virus Type A H7N7 subtype mouse monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-VT-P188-Ag01
Product Name	Recombinant Avian Influenza Virus Type A H7N7 subtype protein
Pathogen	Avian Influenza Virus Type A H7N7 subtype
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Avian Influenza Virus Type A H7N7 subtype antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Avian Influenza Virus Type A H7N7 subtype level test of animal Avian/Bird/Poultry infectious disease with Avian influenza.
Tag	His
Product description	Recombinant Avian Influenza Virus Type A H7N7 subtype proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P188-Ab01,GMP-VT-P188-Ab02
Pathogen	Avian Influenza Virus Type A H7N7 subtype
Product Name	Anti-Avian Influenza Virus Type A H7N7 subtype mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Avian Influenza Virus Type A H7N7 subtype antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Avian Influenza Virus Type A H7N7 subtype antibodies in Avian Influenza Virus Type A H7N7 subtype level test of animal Avian/Bird/Poultry infectious disease with Avian influenza.
Product description	Anti-Avian Influenza Virus Type A H7N7 subtype mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Avian Influenza Virus Type A H7N7 subtype antibodies./td>
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Pathogen

Avian Influenza Virus Type A H7N7: A Comprehensive Examination

Influenza A Virus (H7N7), a subtype of the Influenza A virus, represents a significant pathogen with crucial implications for both avian and human health. Understanding its classification, structure, hosts, associated diseases, and diagnostic methods is essential for effective surveillance, prevention, and management.

1. Pathogen Name and Description:

Pathogen Name: Influenza A Virus (H7N7)

Description: Influenza A viruses are members of the Orthomyxoviridae family. Among these, H7N7 is characterized by its segmented genome, which encodes vital viral proteins. Two key surface proteins, hemagglutinin (H7) and neuraminidase (N7), define this subtype. Hemagglutinin plays a crucial role in the virus's attachment to host cells, while neuraminidase facilitates the release of new viral particles.

2. Pathogen Classification:

Classification: Influenza A Virus (Orthomyxoviridae)

Description: Influenza A viruses belong to the Orthomyxoviridae family, a group of enveloped RNA viruses. The "A" designation reflects their distinctiveness, highlighting their segmented genome, which allows for genetic reassortment and the emergence of novel strains. The H7N7 subtype is one of the many variations within the Influenza A virus group.

3. Pathogen Structure (Main Gene and Protein):

Main Gene: The Influenza A H7N7 subtype is characterized by various genes, including those encoding hemagglutinin (H) and neuraminidase (N), which determine the virus's subtype and pathogenicity. These genes are organized within the viral genome segments.

Proteins: Hemagglutinin (H7) and neuraminidase (N7) are the primary surface proteins of the H7N7 subtype. Hemagglutinin is responsible for the initial attachment of the virus to host cells by binding to sialic acid receptors, enabling the virus to enter the host cell. Neuraminidase, on the other hand, is critical for the release of newly formed viral particles from infected cells, a process that aids in viral spread.

4. Hosts Infected and Associated Diseases:

Hosts Infected: The primary hosts for Influenza A H7N7 are avian species, particularly birds. Wild birds, domestic poultry, and waterfowl are known reservoirs for this virus. However, H7N7 has demonstrated the potential for zoonotic transmission, resulting in infections in humans and other mammalian species.

Associated Diseases: In avian hosts, H7N7 infections can lead to Avian Influenza (AI) or "bird flu." The severity of the disease can vary, with some strains causing mild respiratory symptoms and others being highly pathogenic, resulting in severe disease and mortality in poultry. In human infections, symptoms can range from mild influenza-like illness to severe respiratory distress. The zoonotic potential of H7N7 raises concerns about the emergence of novel strains with pandemic potential, emphasizing the importance of surveillance and prevention measures.

5. Diagnostic Methods (Including Nucleic Acids):

Diagnostic Methods: Several diagnostic techniques are utilized for the detection and characterization of Influenza A H7N7. These methods play a vital role in early detection, surveillance, and outbreak management.

Nucleic Acid-Based Techniques: Polymerase Chain Reaction (PCR) and Reverse Transcription-PCR (RT-PCR) are commonly employed to detect the viral nucleic acids in clinical samples. These techniques target specific gene sequences, including hemagglutinin (H) and neuraminidase (N) genes, to identify and subtype the virus. Next-generation sequencing (NGS) is a powerful tool for whole-genome sequencing and further characterization of the virus.

Serological Assays: Enzyme-Linked Immunosorbent Assay (ELISA) and Hemagglutination Inhibition (HI) tests are used to detect antibodies produced in response to H7N7 infection. These assays are valuable for assessing prior exposure in both human and avian populations.

Viral Isolation: Virus isolation involves culturing the virus in cell lines to confirm the presence of the virus and further characterize its properties.

In conclusion, Influenza A Virus (H7N7) represents a significant pathogen with a propensity for zoonotic transmission, making it crucial for both avian and human health. This comprehensive examination of its classification, structure, hosts, associated diseases, and diagnostic methods underscores the need for continued vigilance, research, and public health measures to mitigate the potential risks associated with this virus.

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