Reticuloendotheliosis Virus gp90 antibody and antigen (recombinant protein)

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Diagnostic anti-Reticuloendotheliosis Virus gp90 antibodies pairs and antigen for animal health (animal Avian/Bird/Poultry infectious disease Reticuloendotheliosis) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-VT-P190-Tg001-Ag01	Recombinant Reticuloendotheliosis Virus gp90 protein	$3090.00
GMP-VT-P190-Tg001-Ab01	Anti-Reticuloendotheliosis Virus gp90 mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P190-Tg001-Ab02	Anti-Reticuloendotheliosis Virus gp90 mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P190-Tg001-Ab03	Anti-Reticuloendotheliosis Virus gp90 human monoclonal antibody (mAb)	$3090.00
GMP-VT-P190-Tg001-Ab04	Anti-Reticuloendotheliosis Virus gp90 human monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-VT-P190-Tg001-Ag01
Product Name	Recombinant Reticuloendotheliosis Virus gp90 protein
Pathogen	Reticuloendotheliosis Virus
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Reticuloendotheliosis Virus gp90 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Reticuloendotheliosis Virus level test of animal Avian/Bird/Poultry infectious disease with Reticuloendotheliosis.
Tag	His
Product description	Recombinant Reticuloendotheliosis Virus gp90 proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P190-Tg001-Ab01,GMP-VT-P190-Tg001-Ab02
Pathogen	Reticuloendotheliosis Virus
Product Name	Anti-Reticuloendotheliosis Virus gp90 mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Reticuloendotheliosis Virus gp90 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Reticuloendotheliosis Virus antibodies in Reticuloendotheliosis Virus level test of animal Avian/Bird/Poultry infectious disease with Reticuloendotheliosis.
Product description	Anti-Reticuloendotheliosis Virus gp90 mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Reticuloendotheliosis Virus antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P190-Tg001-Ab03,GMP-VT-P190-Tg001-Ab04
Pathogen	Reticuloendotheliosis Virus
Product Name	Anti-Reticuloendotheliosis Virus gp90 human monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	Recombinant Reticuloendotheliosis Virus gp90 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Reticuloendotheliosis Virus antibodies in Reticuloendotheliosis Virus level test of animal Avian/Bird/Poultry infectious disease with Reticuloendotheliosis.
Product description	Anti-Reticuloendotheliosis Virus gp90 mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Pathogen Information

Reticuloendotheliosis Virus (REV), a member of the Retroviridae family, is a retrovirus that infects fowl, causing lymphoid leukosis and reticuloendotheliosis. This pathogen is transmitted through the respiratory and oral routes, and also through the cloaca during contact with contaminated feces. The virus can also be transmitted vertically from infected hens to their offspring.

REV primarily infects the lymphoid tissues of chickens, particularly the bursa of Fabricius and the spleen. Upon infection, the virus causes transformation of lymphocytes and other cells in these tissues, leading to tumor formation. The tumors resulting from REV infection are usually B-cell lymphomas, but T-cell lymphomas have also been reported. These tumors are often found in the liver, spleen, kidneys, gonads, and other internal organs.

The pathogenesis of REV infection involves the integration of viral DNA into the host genome, causing the expression of viral genes and the production of viral particles. The virus can also induce the expression of cellular oncogenes, which promote the growth and proliferation of infected cells.

REV infection can result in a range of clinical signs in chickens, including reduced growth rate, weight loss, decreased egg production, and immune suppression. In severe cases, affected birds may suffer from paralysis, blindness, and other neurological signs. Mortality rates vary widely depending on the severity of the disease, ranging from less than 1% to over 30%.

Diagnostic methods for REV infection include PCR and ELISA tests, which detect viral DNA and antigens in blood or tissue samples. The PCR test is highly sensitive and specific, and can detect very low levels of viral DNA in infected tissues or secretions. The ELISA test detects the presence of antibodies against REV, indicating that the bird has been exposed to the virus, and is commonly used for serological surveillance in commercial flocks.

In addition, virus isolation and histopathology can also be used to detect and characterize REV infection. Virus isolation involves the propagation of the virus in cell culture, followed by detection of viral antigens or nucleic acids. Histopathology involves examination of tissue samples for evidence of tumor formation or other changes associated with REV infection.

Prevention and control of REV infection involves strict biosecurity measures, such as the use of disinfectants, proper disposal of dead birds, and isolation of infected animals. Vaccination is also available, but may not provide complete protection against all strains of the virus. Treatment options for REV infection are limited and often ineffective, so early detection and prevention are critical for controlling the spread of this pathogen.

In conclusion, Reticuloendotheliosis Virus is a retrovirus that primarily infects chickens, causing neoplastic diseases and immune suppression. The virus is transmitted through multiple routes and can have significant economic impact on commercial poultry operations. Diagnostic methods for REV infection include PCR, ELISA, virus isolation, and histopathology, while prevention and control strategies involve strict biosecurity measures and vaccination.

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